Results 141 to 150 of about 94,058 (273)

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

open access: yesThe FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu   +7 more
wiley   +1 more source

Deletion of Cardiac miR-17-92 Cluster Increases Ischemia/ Reperfusion Injury via PTEN Upregulation [PDF]

open access: yes, 2017
The miR-17- 92 cluster is necessary for cell proliferation and development of the cardiovascular system. Deletion of this cluster leads to death in neonatal mice.
Prakash, Meeta B
core   +1 more source

The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]

open access: yes, 2015
The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio   +3 more
core   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

open access: yesThe FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman   +13 more
wiley   +1 more source

Studies on Some Enzyme Activities in Laminated and Germinal Layers of Hydatid Cysts Isolated From Different Intermediate Hosts in Zakho, Duhok Province, Kurdistan Region of Iraq.

open access: yesScience Journal of University of Zakho, 2014
The current study deals with some enzyme activities in laminated and germinal layers of hydatid cysts isolated from liver and lungs of infected sheep, goats and cattle slaughtered in Zakho abattoirs and cysts isolated from humans.
Wijdan M.S. Mero, Araz R.I. AL Bosely
doaj  

Development of conductometric biosensors based on alkaline phosphatases for the water quality control [PDF]

open access: yesarXiv, 2008
Researches are focused on the elaboration of enzymatic microconductometric device for heavy metal ions detection in water solutions. The manuscript includes a general introduction, the first chapter contains bibliographic review, the second chapter described the fundamentals of conductometric transducers, the third chapter examining the possibility to ...
arxiv  

Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells [PDF]

open access: yes, 2015
The aim of the study was to analyze molecular mechanisms involved in follicle-stimulating hormone (FSH) and basic Fibroblast Growth Factor (bFGF) regulation of lactate production in rat Sertoli cells.
Artagaveytia, Silvana Lucía   +6 more
core   +1 more source

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

open access: yesJournal of Phycology, EarlyView.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner   +3 more
wiley   +1 more source

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

open access: yes, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P   +6 more
core   +1 more source

At‐RS31 orchestrates hierarchical cross‐regulation of splicing factors and integrates alternative splicing with TOR‐ABA pathways

open access: yesNew Phytologist, EarlyView.
Summary Alternative splicing is essential for plants, enabling a single gene to produce multiple transcript variants to boost functional diversity and fine‐tune responses to environmental and developmental cues. Arabidopsis thaliana At‐RS31, a plant‐specific splicing factor in the Serine/Arginine‐rich (SR) protein family, responds to light and the ...
Tino Köster   +18 more
wiley   +1 more source

Home - About - Disclaimer - Privacy