Results 181 to 190 of about 59,248 (212)
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
The activity of mammalian pyruvate dehydrogenase complex (PDC) is regulated by a phosphorylation/dephosphorylation cycle. Dephosphorylation accompanied by activation is carried out by two genetically different isozymes of pyruvate dehydrogenase phosphatase, PDP1c and PDP2c.
Svitlana Danchuk +3 more
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The activity of mammalian pyruvate dehydrogenase complex (PDC) is regulated by a phosphorylation/dephosphorylation cycle. Dephosphorylation accompanied by activation is carried out by two genetically different isozymes of pyruvate dehydrogenase phosphatase, PDP1c and PDP2c.
Svitlana Danchuk +3 more
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Archives of Biochemistry and Biophysics, 1985
The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
Thomas R. Mullinax +3 more
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The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
Thomas R. Mullinax +3 more
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Biochemical and Biophysical Research Communications, 1977
Abstract Evidence is presented that phosphopeptides produced by tryptic digestion of phosphorylated pyruvate dehydrogenase are effective substrates for pyruvate dehydrogenase phosphatase and that the dephosphopeptides can serve as substrates for pyruvate dehydrogenase kinase.
Paul F. Davis +2 more
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Abstract Evidence is presented that phosphopeptides produced by tryptic digestion of phosphorylated pyruvate dehydrogenase are effective substrates for pyruvate dehydrogenase phosphatase and that the dephosphopeptides can serve as substrates for pyruvate dehydrogenase kinase.
Paul F. Davis +2 more
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Insulin mediator stimulation of pyruvate dehydrogenase phosphatases
Archives of Biochemistry and Biophysics, 1992A two stage assay for detecting insulin mediator based upon its stimulation of soluble pyruvate dehydrogenase (PDH) phosphatase to activate soluble pyruvate dehydrogenase complex (PDC) has been developed. This coupled assay determines the activation of PDC by monitoring production of [14C]CO2 from [1-14C]pyruvic acid.
C. Zhang +4 more
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Function of calcium ions in pyruvate dehydrogenase phosphatase activity
Biochemical and Biophysical Research Communications, 1972Abstract Phosphorylation and dephosphorylation of the pyruvate dehydrogenase (PDH) component of the mammalian pyruvate dehydrogenase complex are catalyzed, respectively, by a MgATP2-requiring kinase and a Mg2+-requiring phosphatase. The kinase and the PDH, but not the phosphatase, are tightly bound to the dihydrolipoyl transacetylase core of the ...
Thomas E. Roche +2 more
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Pyruvate dehydrogenase phosphatase
1996Four classes of protein serine/threonine phosphatases have been identified in eukaryotic cells on the basis of substrate specificities and sensitivity to activators and inhibitors (Cohen, 1989; Shenolikar and Nairn, 1991). Protein phosphatase 1 is sensitive to the thermostable proteins inhibitor 1 and inhibitor 2, and protein phosphatases 1 and 2A are ...
Lester J. Reed +3 more
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Identification of a canine model of pyruvate dehydrogenase phosphatase 1 deficiency
Molecular Genetics and Metabolism, 2006Exercise intolerance syndromes are well known to be associated with inborn errors of metabolism affecting glycolysis (phosphorylase and phosphofructokinase deficiency) and fatty acid oxidation (palmitoyl carnitine transferase deficiency). We have identified a canine model for profound exercise intolerance caused by a deficit in PDP1 (EC 3.1.3.43), the ...
Neviana MacKay +5 more
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[67] Pyruvate dehydrogenase phosphatase from bovine heart
1982Publisher Summary This chapter discusses the procedure of purification of pyruvate dehydrogenase phosphatase from both heart and kidney mitochondria. Pyruvate dehydrogenase phosphatase is a mitochondrial enzyme that catalyzes dephosphorylation and concomitant reactivation of the phosphorylated, inactive pyruvate dehydrogenase component (E l ) of the ...
Flora H. Pettit +2 more
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Assay of Insulin Mediator Activity with Soluble Pyruvate Dehydrogenase Phosphatase
Endocrinology, 1985The putative mediator of intracellular insulin action has been assayed quantitatively by its ability to increase the activity of solubilized pyruvate dehydrogenase (PDH) phosphatase. Conversion of soluble beef heart PDH b to PDH a by PDH phosphatase increased when incubation was carried out in the presence of a crude insulin mediator fraction generated
J. Bornstein +2 more
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Biochemical Society Transactions, 1988
In starvation, inhibition of the pyruvate dehydrogenase complex (PDH) is associated with activation of PDH kinase secondary to increased fat oxidation through increased mitochondrial acetyl-CoA/CoA and N A D H / N A D + concentration ratios (for review, see Randle, 1986). However, acute inhibition of mitochondria1 fat oxidation by 2-tetradecylglycidate
Mary C. Sugden, Mark J. Holness
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In starvation, inhibition of the pyruvate dehydrogenase complex (PDH) is associated with activation of PDH kinase secondary to increased fat oxidation through increased mitochondrial acetyl-CoA/CoA and N A D H / N A D + concentration ratios (for review, see Randle, 1986). However, acute inhibition of mitochondria1 fat oxidation by 2-tetradecylglycidate
Mary C. Sugden, Mark J. Holness
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