Overexpression of pyruvate dehydrogenase phosphatase 1 promotes the progression of pancreatic adenocarcinoma by regulating energy-related AMPK/mTOR signaling. [PDF]
Cell Biosci, 2020 Background Human pyruvate dehydrogenase phosphatase 1 (PDP1) plays an important physiological role in energy metabolism; however, its expression and function in human pancreatic adenocarcinoma (PDAC) remain unknown.
Li Y +5 more
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A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency. [PDF]
JIMD Rep, 2019 Congenital lactic acidosis due to pyruvate dehydrogenase phosphatase (PDP) deficiency is very rare. PDP regulates pyruvate dehydrogenase complex (PDC) and defective PDP leads to PDC deficiency.
Bedoyan JK +12 more
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Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health
Frontiers in PhysiologyPyruvate dehydrogenase phosphatase (PDP), a structurally conserved member of the protein phosphatase C family (PP2C) of proteins, is a key regulatory enzyme responsible for reactivation of the mitochondrial gate-keeper, pyruvate dehydrogenase (PDH ...
Vikalp Kumar, Miriam L. Greenberg
doaj +3 more sources
Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase. [PDF]
Acta Crystallogr F Struct Biol Commun, 2020 Mammalian pyruvate dehydrogenase (PDH) activity is tightly regulated by phosphorylation and dephosphorylation, which is catalyzed by PDH kinase isomers and PDH phosphatase isomers, respectively. PDH phosphatase isomer 1 (PDP1) is a heterodimer consisting
Guo Y, Qiu W, Roche TE, Hackert ML.
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Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1). [PDF]
J Biol ChemLiang Z +4 more
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Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Th17 cells favor glycolytic metabolism. Pyruvate dehydrogenase, which facilitates entry into the oxidative phosphorylation circle, is inhibited by pyruvate dehydrogenase phosphatase catalytic subunit 2 (PDP2).
Kono M +7 more
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[Pyruvate dehydrogenase phosphatase deficiency]. [PDF]
Ryōikibetsu shōkōgun shirīzu, 2020 Pyruvate dehydrogenase phosphatase deficiency is a very rare subtype of pyruvate dehydrogenase deficiency (PDHD, see this term) characterized by lactic acidemia in the neonatal period.
M. Ito, J. Matsuda
semanticscholar +2 more sources
Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase. [PDF]
J Biol Chem, 2017 The pyruvate dehydrogenase complex (PDC) is the primary metabolic checkpoint connecting glycolysis and mitochondrial oxidative phosphorylation and is important for maintaining cellular and organismal glucose homeostasis.
Guo X, Niemi NM, Coon JJ, Pagliarini DJ.
europepmc +4 more sources
Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi. [PDF]
J Biol Chem, 2018 In vertebrate cells, mitochondrial Ca2+ uptake by the mitochondrial calcium uniporter (MCU) leads to Ca2+-mediated stimulation of an intramitochondrial pyruvate dehydrogenase phosphatase (PDP).
Lander N +5 more
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Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes. [PDF]
Med Sci Sports Exerc, 2016 Barberio MD +5 more
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