Results 191 to 200 of about 59,248 (212)
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Decrease of pyruvate dehydrogenase phosphatase activity in patients with congenital lactic acidemia
Clinica Chimica Acta, 1992We developed an assay method for pyruvate dehydrogenase phosphatase activity using [1-14C]pyruvate and measured pyruvate dehydrogenase phosphatase activity in cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex.
Michinori Ito +6 more
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Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms
2001The mammalian pyruvate dehydrogenase complex (PDC) plays central and strategic roles in the control of the use of glucose-linked substrates as sources of oxidative energy or as precursors in the biosynthesis of fatty acids. The activity of this mitochondrial complex is regulated by the continuous operation of competing pyruvate dehydrogenase kinase ...
Xiaohua Yan +8 more
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Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney
Biochemistry, 1982Pyruvate dehydrogenase phosphatase was purified to apparent homogeneity from bovine heart and kidney mitochondria. The phosphatase has a sedimentation coefficient (S20,w) of about 7.4 S and a molecular weight (Mr) of about 150 000 as determined by sedimentation equilibrium and by gel-permeation chromatography.
Lester J. Reed +4 more
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Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney
Molecular and Cellular Biochemistry, 1995Pyruvate dehydrogenase complex (PDC) from rat kidney or pig heart previously inactivated by phosphorylation (PDHP) was activated in vitro by PDHP phosphatase from kidneys of starved or fed rats. Starvation for 48 h of the rats from which the PDC was prepared led to a decrease in the rate of activation of PDC at early time periods (< 2 min ...
B. N. Cockburn, Haldane G. Coore
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Pyruvate dehydrogenase phosphatase deficiency: Orphan disease or an under-diagnosed condition?
Molecular and Cellular Endocrinology, 2006Pyruvate dehydrogenase phosphatase (PDP) is an enzyme which regulates the activity of the pyruvate dehydrogenase complex (PDHc). In the past, PDHc deficiency has been attributed to mutations in the complex itself and the regulatory enzymes have not been considered.
Brian H. Robinson +2 more
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Biochemistry. Biokhimiia, 1999
Recent experimental findings on the structural--functional features of pyruvate dehydrogenase phosphatase (PDP) isolated from various sources are compared. Two alternative mechanisms (a and b) of dephosphorylation of the E1 component in the pyruvate dehydrogenase complex (PDC) are discussed: a) the reaction occurs as a result of stochastic collisions ...
G L, Ermakov, B N, Goldstein
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Recent experimental findings on the structural--functional features of pyruvate dehydrogenase phosphatase (PDP) isolated from various sources are compared. Two alternative mechanisms (a and b) of dephosphorylation of the E1 component in the pyruvate dehydrogenase complex (PDC) are discussed: a) the reaction occurs as a result of stochastic collisions ...
G L, Ermakov, B N, Goldstein
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The control of pyruvate dehydrogenase phosphate phosphatase by Ca2+ and Mg2+ ions [PDF]
Biochemical Society Transactions, 1987 Richard M. Denton +3 more
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An overview of structure, function, and regulation of pyruvate kinases
Protein Science, 2019Debasish Chattopadhyay +2 more
exaly
Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE)
Angewandte Chemie - International Edition, 2019Fadi Ahwal +2 more
exaly