Results 41 to 50 of about 94,058 (273)

LIGHT-SABRE hyperpolarizes 1-^{13}C-pyruvate continuously, without magnetic field cycling [PDF]

J. Phys. Chem. C 2023, 127, 14, 6744-6753, 2023
Nuclear spin hyperpolarization enables real-time observation of metabolism and intermolecular interactions in vivo. 1-13C-Pyruvate is the leading hyperpolarized tracer currently under evaluation in several clinical trials as a promising molecular imaging agent.
arxiv   +1 more source

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

Scientific Reports, 2023
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice.
Giovan N. Cholico, Karina Orlowska, Russell R. Fling, Warren J. Sink, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Tim Zacharewski   +7 more
doaj   +1 more source

The Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism

Frontiers in Physiology, 2020
Recently, the role of mitochondrial activity in high-energy demand organs and in the orchestration of whole-body metabolism has received renewed attention.
Gaia Gherardi, Halenya Monticelli, Rosario Rizzuto, Cristina Mammucari   +3 more
doaj   +1 more source

The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation

Life Science Alliance, 2023
Mutations in the PDC affect the phosphorylation and mitophagic trafficking of matrix proteins, through the novel regulation of associated kinases and a phosphatase.
Panagiota Kolitsida, Vladimir Nolic, Jianwen Zhou, M. Stumpe, Natalie M. Niemi, J. Dengjel, H. Abeliovich   +6 more
semanticscholar   +1 more source

The pyruvate dehydrogenase complex regulates matrix protein phosphorylation and mitophagic selectivity

bioRxiv, 2023
The mitophagic degradation of mitochondrial matrix proteins in S. cerevisiae was previously shown to be selective, reflecting a pre-engulfment sorting step within the mitochondrial network.
Panagiota Kolitsida, Vladimir Nolic, Jianwen Zhou, M. Stumpe, Natalie M. Niemi, J. Dengjel, H. Abeliovich   +6 more
semanticscholar   +1 more source

Effect of Zinc Exposure on Protein and Activity of Enzymes of Freshwater Mussel Dreissena Polymorpha [PDF]

Kirkuk Journal of Science, 2011
Dreissena polymorpha mussel were collected from Al-Kadesia lake- Haditha /Al-Anbar Governorate-Iraq, between November 2008 and February 2009. The animals were exposed for 4, 8, and 8 mg zinc/L of water for 8 days.
Abid A. Thaker, Ahmad S. Farhan
doaj   +1 more source

FGF2-induced Redox Signaling: A Mechanism Regulating Pyruvate Dehydrogenase Driven Histone Acetylation and NANOG Upregulation

bioRxiv, 2023
Precise control of pluripotency is a requirement for the safe and effective use of hPSCs in research and therapies. Here we report that pyruvate dehydrogenase upregulates histone H3 pan acetylation and levels of pluripotency marker NANOG in 5% O2 ...
P. Fojtík, Martin Šenfluk, Katerina Holomkova, A. Salykin, J. Gregorová, P. Šmak, O. Peš, J. Raška, Monika Štětková, P. Skládal, M. Sedláčková, A. Hampl, Dáša Bohačiaková, S. Uldrijan, V. Rotrekl   +14 more
semanticscholar   +1 more source

Histological, physiological, and transcriptomic responses of hepatopancreas to air exposure in asian freshwater clam Corbicula fluminea

Frontiers in Physiology, 2022
Corbicula fluminea (C. fluminea) is an important freshwater economy shellfish in China, but it often suffers from air exposure during transportation. In this study, we investigated the histological, physiological (mainly including respiratory metabolism,
Ting Zhang, Dongpu Xu, Guohua Lv, Anqi Wang, Haibo Wen   +4 more
doaj   +1 more source

Scanning mutagenesis of the amino acid sequences flanking phosphorylation site 1 of the mitochondrial pyruvate dehydrogenase complex

Frontiers in Plant Science, 2012
The mitochondrial pyruvate dehydrogenase complex is regulated by reversible seryl-phosphorylation of the E1α subunit by a dedicated, intrinsic kinase. The phospho-complex is reactivated when dephosphorylated by an intrinsic PP2C-type protein phosphatase.
Nagib eAhsan, Kirby eSwatek, Jingfen eZhang, Ján Andrew Miernyk, Dong eXu, Jay eThelen   +5 more
doaj   +1 more source

Effect of exposure to sublethal concentrations of sodium cyanide on the carbohydrate metabolism of the Indian Major Carp Labeo rohita (Hamilton, 1822)

Pesquisa Veterinária Brasileira, 2013
Experiments were designed to study in-vivo effects of sodium cyanide on biochemical endpoints in the freshwater fish Labeo rohita. Fish were exposed to two sublethal concentrations (0.106 and 0.064mg/L) for a period of 15 days.
Praveen N. Dube, Shwetha Alavandi, Basaling B. Hosetti   +2 more
doaj   +1 more source