Results 51 to 60 of about 94,058 (273)
Molecules and Cells, 2022 DJ-1 is one of the causative genes of early-onset familial Parkinson’s disease (PD). As a result, DJ-1 influences the pathogenesis of sporadic PD. DJ-1 has various physiological functions that converge to control the levels of intracellular reactive ...
Y. Lee +8 more
semanticscholar +1 more source
Inhibition of adaptive therapy tolerance in cancer: is triplet mitochondrial targeting the key?
Molecular Oncology, 2023 Targeted therapies have become a mainstay in the treatment of cancer, but their long‐term efficacy is compromised by acquired drug resistance. Acquired therapy resistance develops via two phases—first through adaptive development of nongenetic drug ...
Jukka Westermarck
doaj +1 more source
Frontiers in Veterinary Science, 2023 Trichinella spiralis (T. spiralis) muscle-larva excretory/secretory products (ML-ESPs) is a complex array of proteins with antitumor activity. We previously demonstrated that ML-ESPs inhibit the proliferation of A549 non-small cell lung cancer (NSCLC ...
Haoxuan Wang +7 more
doaj +1 more source
Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1- 13 C]pyruvate [PDF]
, 2021 ParaHydrogen Induced Polarization-Side Arm Hydrogenation (PHIP-SAH) is an inexpensive tool to obtain hyperpolarized pyruvate (and other metabolites) that can be applied to in-vivo diagnostics, for the investigation of metabolic processes. This method is based on hydrogenation, using hydrogen enriched in the para-isomer, of unsaturated substrates ...
arxiv +1 more source
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase [PDF]
J Theor Biol 240: 464-474 (2006), 2005 Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 erythroleukemia cells. MAP kinase pathway activation alters the expression of metabolic enzymes in K562 cells.
arxiv +1 more source
A Metabolite Specific 3D Stack-of-Spiral bSSFP Sequence for Improved Lactate Imaging in Hyperpolarized [1-$^{13}$C]Pyruvate Studies on a 3T Clinical Scanner [PDF]
Magn Reson Med. 2020; 84: 1113-1125, 2020 Purpose: The balanced steady-state free precession sequence has been previously explored to improve the efficient use of non-recoverable hyperpolarized $^{13}$C magnetization, but suffers from poor spectral selectivity and long acquisition time. The purpose of this study was to develop a novel metabolite-specific 3D bSSFP ("MS-3DSSFP") sequence with ...
arxiv +1 more source
Animals, 2023 This study was designed to examine the protective effects of the extract of mulberry (Morus alba L.) leaves (EML) on crucian carp (Carassius auratus) against a high stocking density, Cu exposure and trichlorfon exposure, which adversely impact fish ...
Gangfu Chen +8 more
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Antibacterial Activity and Mechanism of Linalool against Shewanella putrefaciens
Molecules, 2021 The demand for reduced chemical preservative usage is currently growing, and natural preservatives are being developed to protect seafood. With its excellent antibacterial properties, linalool has been utilized widely in industries.
Fengyu Guo +7 more
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Radical-free hyperpolarized MRI using endogenously-occurring pyruvate analogues and UV-induced nonpersistent radicals [PDF]
, 2020 It was demonstrated that nonpersistent radicals can be generated in frozen solutions of metabolites such as pyruvate by irradiation with ultraviolet (UV) light, enabling radical-free dissolution DNP. Although pyruvate is endogenous, an excess of additional pyruvate may perturb metabolic processes, making it potentially unsuitable as a polarizing agent ...
arxiv +1 more source
Metabolism Open, 2021 Background: Telfairia occidentalis (TO), a plant consumed for its nutritional and medicinal values, exhibits hypoglycaemic effect. However, the metabolic fate of the glucose following TO-induced insulin secretion and consequent hypoglycaemia is not clear.
Toyin Mohammed Salman +4 more
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