Results 61 to 70 of about 59,248 (212)

Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein

Frontiers in Cell and Developmental Biology, 2020
The dynamic interplay between virus and host proteins is critical for establishing efficient viral replication and virus-induced pathogenesis. Phosphorylation-dependent prolyl isomerization by Pin1 provides a unique mechanism of molecular switching to ...
Mayuko Nishi, Kei Miyakawa, Satoko Matsunaga, Hajera Khatun, Yutaro Yamaoka, Yutaro Yamaoka, Koichi Watashi, Masaya Sugiyama, Hirokazu Kimura, Takaji Wakita, Akihide Ryo   +10 more
doaj   +1 more source

Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by phosphorylation [PDF]

, 2019
Protein phosphorylation and membrane proteins play an important role in the infection of plants by phytopathogenic fungi, given their involvement in signal transduction cascades.
Amil, Francisco, Blanco-Ulate, Barbara, Cantoral Fernández, Jesús Manuel, Carrasco, Rafael, Chiva, Cristina, Escobar Niño, Almudena, Fernández Acero, Francisco Javier, Fuentes, Carlos, Lineiro, Eva, Sabido, Eduard   +9 more
core   +2 more sources

Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells

Scientific Reports, 2022
Therapeutic resistance to kinase inhibitors constitutes a major unresolved clinical challenge in cancer and especially in glioblastoma. Multi-kinase inhibitors may be used for simultaneous targeting of multiple target kinases and thereby potentially ...
Oxana V. Denisova, Joni Merisaari, Amanpreet Kaur, Laxman Yetukuri, Mikael Jumppanen, Carina von Schantz-Fant, Michael Ohlmeyer, Krister Wennerberg, Tero Aittokallio, Mikko Taipale, Jukka Westermarck   +10 more
doaj   +1 more source

Purification and characterization of recombinant pyruvate dehydrogenase kinases from pea and soybean plants [abstract] [PDF]

, 2006
only availableFaculty Mentor: Dr. Douglas Randall, BiochemistryThe pyruvate dehydrogenase complex (PDC) is a large multienzyme complex catalyzing the oxidative decarboxylation of pyruvate and concomitant reduction of NAD to yield acetyl-CoA and NADH ...
Hoyos, Elizabeth, Miernyk, Ján A., 1947-, Smith-Hammond, Colin L., Tovar-Mendez, Alejandro   +3 more
core  

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. [PDF]

, 2019
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ...
Adams, Alfadhel, Alfadhel, Alfadhel, Aljabri, Anwar, Aronson, Arts, Attwell, Baio, Banka, Barennes, Benton, Bettendorff, Bettendorff, Biesecker, Brown, Butterworth, Butterworth, Butterworth, Calhau, Carney, Chandrakumar, Chen, Cheung, Chornyy, Chugani, Colbert, Croft, Day, De Meirleir, Fattal-Valevski, Fattal-Valevski, Fleming, Forouhi, Foulon, Foulon, Fraccascia, Fraccascia, Fraser, Frustaci, Fujita, Galvin, Ganapathy, Gangolf, Ganie, Ghaleiha, Gibson, Giulivi, Gold, Greenwood, Gu, Harel, Hiffler, Hilker, Inaba, Ishaque, Israels, Jankowska-Kulawy, Junior, Kamasak, Karabatsiakis, Kelley, Kerns, Khaw, Kitamura, Kornreich, Kril, Laforenza, Leichter, Lindhurst, Liu, Lonsdale, Lonsdale, Lonsdale, Lorber, Lu, Lukienko, Luxemburger, Lương, Ma, Magos, Mahajan, Mahmood, Martel, Martin, Mayr, McLure, Mergenthaler, Mezzar, Mimouni-Bloch, Molina, Mulholland, Mulle, Muoio, Murata, Nabokina, Nabokina, Nardone, Navarro, Nikseresht, Obrenovich, Oishi, Opdenakker, Ortega Garcia, Ortigoza-Escobar, Pepersack, Perez-Duenas, Plaitakis, Prabakaran, Prohaska, Rabie, Randle, Renthal, Rindi, Rindi, Robinson, Roust, Rubio-Lopez, Said, Schaller, Scrimshaw, Sequeira Lopes da Silva, Shi, Singleton, Siu, Skjeldal, Smidt, Society, Song, Sperringer, Spiegel, Stargrove, Subramanian, Subramanian, Sweet, Tabarki, Talwar, Thomson, Thornalley, van den Brink, Vasconcelos, Vernau, Vernau, Vimokesant, Watkins, Wendel, Whitfield, Whitfield, Wierzbicki, Williams, Yang, Zhang, Zhao, Zuccoli   +154 more
core   +2 more sources

The metabolic advantage of tumor cells

Molecular Cancer, 2011
1- Oncogenes express proteins of "Tyrosine kinase receptor pathways", a receptor family including insulin or IGF-Growth Hormone receptors. Other oncogenes alter the PP2A phosphatase brake over these kinases.
Schwartz Laurent, Israël Maurice
doaj   +1 more source

Purification and Characterization of Pyruvate‐Dehydrogenase Phosphatase from Pig‐Heart Muscle [PDF]

European Journal of Biochemistry, 1972
Pyruvate‐dehydrogenase phosphatase was extensively purified from pig heart muscle. The molecular weight was determined to be in the range between 92000 and 95000. By dodecylsulfate‐gel electrophoresis there was no indication for a subunit structure of the protein. The phosphatase is dependent on Mg2+ or Mn2+.
Otto H. Wieland, Elmar A. Siess
openaire   +3 more sources

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]

, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A., Berasain, Carmen, Brozzetti, Stefania, Calvisi, Diego F., Daino, Lucia, Demartis, Maria I., Feo, Claudio F., Feo, Francesco, Latte, Gavinella, Pascale, Rosa M., Porcu, Alberto, Seddaiu, Maria A., Simile, Maria M., Tomasi, Maria L.   +13 more
core   +2 more sources

Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae. [PDF]

PLoS ONE, 2013
Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive
Asier González, Carlos Casado, Joaquín Ariño, Antonio Casamayor   +3 more
doaj   +1 more source