Results 71 to 80 of about 94,058 (273)
Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
Frontiers in Cell and Developmental Biology, 2020 The dynamic interplay between virus and host proteins is critical for establishing efficient viral replication and virus-induced pathogenesis. Phosphorylation-dependent prolyl isomerization by Pin1 provides a unique mechanism of molecular switching to ...
Mayuko Nishi +10 more
doaj +1 more source
Purification and characterization of recombinant pyruvate dehydrogenase kinases from pea and soybean plants [abstract] [PDF]
, 2006 only availableFaculty Mentor: Dr. Douglas Randall, BiochemistryThe pyruvate dehydrogenase complex (PDC) is a large multienzyme complex catalyzing the oxidative decarboxylation of pyruvate and concomitant reduction of NAD to yield acetyl-CoA and NADH ...
Hoyos, Elizabeth +3 more
core
Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]
, 2016 Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K. +2 more
core +3 more sources
Advanced Science, EarlyView.Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian +16 more
wiley +1 more source
REPEATED ACUTE STRESS INDUCED ALTERATIONS IN CARBOHYDRATE METABOLISM IN RAT [PDF]
Journal of Stress Physiology & Biochemistry, 2010 Acute stress induced alterations in the activity levels of rate limiting enzymes and concentration of intermediates of different pathways of carbohydrate metabolism have been studied.
Nirupama R., Devaki M., Yajurvedi H. N.
doaj
Scientific Reports, 2022 Therapeutic resistance to kinase inhibitors constitutes a major unresolved clinical challenge in cancer and especially in glioblastoma. Multi-kinase inhibitors may be used for simultaneous targeting of multiple target kinases and thereby potentially ...
Oxana V. Denisova +10 more
doaj +1 more source
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]
, 2008 Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core +1 more source
Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]
, 2016 Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A. +13 more
core +1 more source
Advanced Science, EarlyView.Enhanced arginine uptake is a critical feature of metabolic reprogramming in PTCL, characterized by elevated expression of the arginine transporter SLC3A2. SLC3A2‐mediated arginine uptake facilitates PTCL proliferation and survival by enhancing OXPHOS metabolism and inducing immune evasion.
Yimin Ren +13 more
wiley +1 more source