Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia+29 more
wiley +1 more source
Mode of action of vitamin D. The effect of vitamin D deficiency in the rat on anaerobic glycolysis and pyruvate oxidation by epiphyseal cartilage [PDF]
P. G. Tulpule, V. N. Patwardhan
openalex +1 more source
IMMUNOSUPPRESSION AFTER EXPERIMENTAL AND CLINICAL HOMOTRANSPLANTATION [PDF]
KIRKPATRICK, CH+6 more
core +1 more source
Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet
The phototoxicity in nonlinear optical microscopy arises mainly from linear absorption of intrinsic biomolecules rather than nonlinear absorption. This mechanism is supported by a reproducible phototoxicity assay based on widely available chicken breast.
Geng Wang+4 more
wiley +1 more source
The effects of diatom pore-size on the structures and extensibilities of single mucilage molecules [PDF]
Alam+55 more
core +1 more source
Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen+11 more
wiley +1 more source
Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu+8 more
wiley +1 more source
THE ENZYMATIC SYNTHESIS OF PHOSPHOPYRUVATE FROM PYRUVATE
Henry A. Lardy, John A. Ziegler
openalex +1 more source
The oxidation of pyruvate and fatty acids by Mycobacterium ranae [PDF]
Monica Lindsay+2 more
openalex +1 more source
Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang+28 more
wiley +1 more source