Results 161 to 170 of about 23,768 (211)

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

NRF2 Plays a Crucial Role in the Tolerogenic Effect of Ethyl Pyruvate on Dendritic Cells. [PDF]

Int J Mol Sci
Stanisavljević S, Stegnjaić G, Jevtić B, Dimitrijević M, Miljković Đ, Lavrnja I, Nikolovski N.   +6 more
europepmc   +1 more source

The Pyruvate Dehydrogenase Complex: Nutrient Control and the Pathogenesis of Insulin Resistance

, 1995
Mary C. Sugden, Karen A. Orfali, Mark J. Holness   +2 more
openalex   +1 more source

Targeting the SOX9/TIMP1 Axis with iRGD‐Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer

Advanced Science, EarlyView.
This study identifies the SOX9/TIMP1 axis as a key regulator of immune evasion in gastric cancer. iRGD‐conjugated nanoparticles co‐delivering si‐SOX9, Ce6, and L‐Arg are developed to synergize with photodynamic therapy. The nanoplatform suppresses tumor growth, promotes dendritic cell maturation, and enhances CD8+ T‐cell activation, offering a ...
Banghua Zhong, Yijie Zhang, Honghu Wang, Lili Guo   +3 more
wiley   +1 more source

Concepts of a synthetic minimal cell: Information molecules, metabolic pathways, and vesicle reproduction. [PDF]

Biophys Physicobiol
Kurisu M, Imai M.
europepmc   +1 more source

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

Low-biomass pyruvate production with engineered Vibrio natriegens is accompanied by parapyruvate formation. [PDF]

Microb Cell Fact
Hädrich M, Scheuchenegger C, Vital ST, Gunkel C, Müller S, Hoff J, Borger J, Glawischnig E, Thoma F, Blombach B.   +9 more
europepmc   +1 more source

Imaging resistance to anti-androgens in prostate cancer by multimodal 13C-pyruvate hyperpolarized magnetic resonance spectroscopy and 18F-pivalate positron emission tomography

Prasanta Dutta, José Enríquez, Onder Otlu, Maryam Shariati, Peter Shepherd, Aldo Morales, Vincenzo Paolillo, Estefania Labanca, Pratip Bhattacharya, Federica Pisaneschi   +9 more
openalex   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Identification of altered blood metabolic pathways in equines following ethyl pyruvate administration using non-targeted metabolomics. [PDF]

Sci Rep
Kwak YB, Seo SA, Kim M, Yoon J.
europepmc   +1 more source