Results 271 to 280 of about 95,354 (345)

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Ethyl Pyruvate Decreases Collagen Synthesis and Upregulates MMP Activity in Keloid Fibroblasts and Keloid Spheroids. [PDF]

Int J Mol Sci
Baek W, Park S, Lee Y, Roh H, Yun CO, Roh TS, Lee WJ.   +6 more
europepmc   +1 more source

Negligible In Vitro Recovery of Macromolecules from Microdialysis Using 100 kDa Probes and Dextran in Perfusion Fluid. [PDF]

Neurochem Res
Dorothee S, Sørensen G, Olsen LR, Bastlund JF, Sotty F, Belling D, Olsen MH, Mathiesen TI, Møller K, Larsen F, Birkeland P.   +10 more
europepmc   +1 more source

The RNF/NQR redox pumps: a versatile system for energy transduction in bacteria and archaea. [PDF]

Appl Microbiol Biotechnol
Buckel W, Ermler U, Vonck J, Fritz G, Steuber J.   +4 more
europepmc   +1 more source

A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in Escherichia coli

Zhang J, Yu K, Xu Y, Zhao W, Li Y, Wang Y, Seebeck FP, Chen X, Liao C.   +8 more
europepmc   +1 more source

M6A methyltransferase METTL3 promotes glucose metabolism hub gene expression and induces metabolic dysfunction-associated steatotic liver disease (MASLD). [PDF]

BMC Genomics
Wang S, Xu Z, Wang Z, Yi X, Wu J.
europepmc   +1 more source

Photo-Thermally Controllable Tumor Metabolic Modulation to Assist T Cell Activation for Boosting Immunotherapy. [PDF]

Int J Nanomedicine
Ma J, Hua L, Zhu Y, Mao G, Fu C, Qin S.
europepmc   +1 more source

Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex [PDF]

Journal of Inherited Metabolic Disease, 1996
SummaryThe most common defect associated with deficiency of the pyruvate dehydrogenase (PDH) complex occurs in the E1 component, specifically due to mutations in the X‐linked E1α gene. Clinical sequelae of these mutations, which range from severe neonatal lactic acidosis to carbohydrate‐sensitive ataxia, can be different in males and females depending ...
Mingfu Ling, Brian H. Robinson, Kathy Chun, N. MacKay   +3 more
openaire   +2 more sources

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Substrate activation of pyruvate carboxylase by pyruvate

Biochemical and Biophysical Research Communications, 1969
Abstract A kinetic analysis of pyruvate carboxylase isolated from sheep liver and using pyruvate as the variable substrate revealed non-Michaelis Menten kinetic. Double reciprocal plots were biphasic and R S values of 222 were obtained. Hill plots prepared from the initial velocity data showed that at low pyruvate concentrations, the slope of the ...
J. Nielsen, D.B. Keech, Helen Taylor
openaire   +3 more sources