Results 51 to 60 of about 1,838,482 (246)

q-Calculus and the Symmetrized Radioactive Decay Law

, 2021
The radioactive decay law was first formulated by Ernest Rutherford and Frederick Soddy in 1902. As a well-known law, one of its primary applications is to determine the dates of ancient specimens.
Shawn Eastmond
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pseudo-Quantum Fractional Calculus and Existence of Solutions for Delay Pseudo-Fractional Differential Equations in Generalized Banach Spaces

Journal of Mathematics
This paper presents a new framework of pseudo-q–fractional calculus in generalized Banach spaces by bringing together pseudo-analysis, G–calculus, and quantum calculus. We introduce Liouville–Caputo and Riemann–Liouville pseudo-q–fractional operators and
Alireza Hatami, Reza Saadati, Mohammad Bagher Ghaemi, Donal O’Regan   +3 more
doaj   +1 more source

Exploring Fractional $q$-Kinetic Equations via Generalized $q$-Mittag-Leffler Type Functions: Applications and Analysis [PDF]

Sahand Communications in Mathematical Analysis
In this study, the $q$-calculus is employed to introduce a novel generalization of the Mittag-Leffler function. In the following, we investigate a novel $q$-exponential function with five parameters, resulting in the generalized $q$-Mittag-Leffler ...
Mulugeta Dawud Ali, Dayalal Suthar, Sunil Purohit   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

New Forms of the Open Newton-Cotes-Type Inequalities for a Family of the Quantum Differentiable Convex Functions [PDF]

Sahand Communications in Mathematical Analysis
The main objective of this paper is to establish some new inequalities related to the open Newton-Cotes formulas in the setting of q-calculus. We establish a quantum integral identity first and then prove the desired inequalities for $q$-differentiable ...
Jarunee Soontharanon, Muhammad Ali, Shahram Rezapour, Muhammad Toseef, Thanin Sitthiwirattham   +4 more
doaj   +1 more source

(p,q)-Hahn Difference Operator [PDF]

, 2020
Master of Science in Mathematics. Institute of Graduate Studies and Research. Thesis (M.S.) - Eastern Mediterranean University, Faculty of Arts and Sciences, Dept. of Mathematics, 2020. Co-Supervisor: Asst. Prof. Dr. Arran Fernandez and Supervisor: Prof.
Malyalı, Duygu
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Some reverse inequalities of Hardy type on time scales

Advances in Difference Equations, 2020
In this article, we obtain some new dynamic inequalities of Hardy type on time scales. The main results are derived using Fubini’s theorem and the chain rule on time scales.
A. A. El-Deeb, H. A. El-Sennary, Zareen A. Khan   +2 more
doaj   +1 more source