Results 61 to 70 of about 13,043 (276)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A note on (p,q) $(p,q)$-Bernstein polynomials and their applications based on (p,q) $(p,q)$-calculus

Journal of Inequalities and Applications, 2018
Nowadays (p,q) $(p,q)$-Bernstein polynomials have been studied in many different fields such as operator theory, CAGD, and number theory. In order to obtain the fundamental properties and results of Bernstein polynomials by using (p,q) $(p,q)$-calculus ...
Erkan Agyuz, Mehmet Acikgoz
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Generalized thermodynamics of q-deformed bosons and fermions

, 2001
We study the thermostatistics of q-deformed bosons and fermions obeying the symmetric algebra and show that it can be built on the formalism of q-calculus.
A. Lavagno, A. Lavagno, A. Macfarlane, C. R. Lee, C. Tsallis, D. F. Torres, E. Baron, E. G. Floratos, F. Jackson, G. Kaniadakis, H. S. Song, J. A. Tuszynski, L. Biedenharn, M. A. Martin-Delgado, M. Chaichian, M. R. Ubriaco, M. Rego-Monteiro, O. W. Greenberg, O. W. Greenberg, P. Narayana Swamy, P. Narayana Swamy, R. J. Finkelstein, Y. J. Ng   +22 more
core   +1 more source

Integral inequalities in q-calculus

Computers & Mathematics with Applications, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Classical and quantum q-deformed physical systems

, 2006
On the basis of the non-commutative q-calculus, we investigate a q-deformation of the classical Poisson bracket in order to formulate a generalized q-deformed dynamics in the classical regime.
241, 27, A. Lavagno, A.M. Scarfone, Abe, Aschieri, Avan, Bardek, Cerchiai, Chaichian, Chaichian, Fichtmueller, Finkelstein, Gruver, Hinterding, Iida, Jackson, Kaniadakis, Klimek, Kwek, Lavagno, Lavagno, Lorek, Lukink, Macfarlane, Micu, P. Narayana Swamy, Reshetikhin, Song, Ubriaco, Wess, Zhang   +31 more
core   +1 more source

Exploring Fractional $q$-Kinetic Equations via Generalized $q$-Mittag-Leffler Type Functions: Applications and Analysis [PDF]

Sahand Communications in Mathematical Analysis
In this study, the $q$-calculus is employed to introduce a novel generalization of the Mittag-Leffler function. In the following, we investigate a novel $q$-exponential function with five parameters, resulting in the generalized $q$-Mittag-Leffler ...
Mulugeta Dawud Ali, Dayalal Suthar, Sunil Purohit   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source