Results 81 to 90 of about 11,741 (260)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Opial's inequality in $q$-Calculus revisited

open access: yes, 2019
We have fundamentally corrected the proofs of the theorems from our paper [9] by giving an entirely different approach, using quite a simple method based on applications of some elementary inequalities, well-known Hölder's inequality, and the Gauchman $q$-restricted integral.
Mirkovic, Tatjana Z.   +2 more
openaire   +2 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

Some Opial-type integral inequalities via (p,q) $(p,q)$-calculus

open access: yesJournal of Inequalities and Applications, 2019
In this paper, we introduce a new Opial-type inequality by using (p,q) $(p,q)$-calculus and establish some integral inequalities. We find a (p,q) $(p,q)$-generalization of a Steffensens-type integral inequality and some other inequalities.
Md. Nasiruzzaman   +2 more
doaj   +1 more source

The Picard and Gauss–Weierstrass Singular Integrals in (p, q)-Calculus

open access: yesBulletin of the Malaysian Mathematical Sciences Society, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
A. Aral, E. Deniz, H. Erbay
openaire   +4 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Remarks on q-calculus and integrability

open access: yes, 2002
Relations between differential calculi, quantum groups, integrable systems, and q-analysis are studied. Some new Hirota type formulas are established for qKP along with variations on classical Hirota formulas.
openaire   +2 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

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