Results 91 to 100 of about 158,926 (265)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Efficient Scheme for Solving Tempered Fractional Quantum Differential Problem

open access: yesFractal and Fractional
This study presents a novel family of operators, referred to as tempered quantum fractional operators, and investigates the well-posedness of related tempered quantum fractional differential equations.
Lakhlifa Sadek, Ali Algefary
doaj   +1 more source

A Note on the (p, q)-Derivative Operator

open access: yesInternational Journal of Applied and Computational Mathematics
AbstractIn this note, for the (p, q)-derivative operator $$D_{p, q}$$ D p , q defined by $$\begin{aligned}D_{p, q}f(x)={\left\{ \begin{array}{ll} \frac{f(px)-f(qx)}{(p-q)x}
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

q-Genocchi Numbers and Polynomials Associated with q-Genocchi-Type l-Functions

open access: yesAdvances in Difference Equations, 2008
The main purpose of this paper is to study on generating functions of the q-Genocchi numbers and polynomials. We prove new relation for the generalized q-Genocchi numbers which is related to the q-Genocchi numbers and q-Bernoulli numbers.
Daeyeoul Kim   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

A Study of an Extended q-Mittag−Leffler Function and Its Image Formula Under the Kober Fractional q-Calculus Operator

open access: yesInternational Journal of Mathematics and Mathematical Sciences
This study uses the q-calculus to present an innovative extension of the q-Mittag−Leffler function. Next, we examine some of its notable characteristics, including image formula under the Kober fractional q-calculus operator, recurrence relation and ...
Mulugeta Dawud Ali, D. L. Suthar
doaj   +1 more source

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