Results 101 to 110 of about 5,587,423 (323)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Some new Hardy-type inequalities for Riemann-Liouville fractional q-integral operator

, 2015
We consider the q-analog of the Riemann-Liouville fractional q-integral operator of order n∈N$n\in N$. Some new Hardy-type inequalities for this operator are proved and discussed.
L. Persson, S. Shaimardan
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A coupled system of fractional q-integro-difference equations with nonlocal fractional q-integral boundary conditions

, 2015
In this paper, we investigate the existence and the uniqueness of solutions for coupled and uncoupled systems of fractional q-integro-difference equations with nonlocal fractional q-integral boundary conditions.
S. Suantai, S. Ntouyas, S. Asawasamrit, J. Tariboon   +3 more
semanticscholar   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

On some new inequalities involving generalized Erdélyi-Kober fractional $q$-integral operator

, 2015
During the past four decades and longer, the subject of fractional calculus (that is, calculus of integrals and derivatives of any arbitrary real or complex order) has provided several potentially useful tools for solving differential, integral and ...
Junesang Choi, D. Ritelli, Praveen Agarwal   +2 more
semanticscholar   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Generalizations of some integral inequalities related to Hardy type integral inequalities via ( p , q ) $(p,q)$ -calculus

, 2021
In this paper, we study generalizations of some integral inequalities related to Hardy type integral inequalities via ( p , q ) $(p, q)$ -calculus. Many results obtained in this paper provide extensions of existing results in the literature. Furthermore,
Jessada Tariboon, Sortiris K. Ntouyas, Kamsing Nonlaopon, Suriyakamol Thongjob   +3 more
core   +1 more source

Higher-order nonlocal multipoint q-integral boundary value problems for fractional q-difference equations with dual hybrid terms

Open Mathematics
In this article, we introduce and study a new class of higher-order fractional q-difference equations involving Riemann-Liouville q-derivatives with dual hybrid terms, supplemented with nonlocal multipoint q-integral boundary conditions. The existence of
Alsaedi Ahmed, Alharbi Boshra, Ahmad Bashir   +2 more
doaj   +1 more source

Hölder’s inequality for shifted quantum integral operator

Examples and Counterexamples
We show by two counterexamples that Hölder’s inequality for shifted quantum integral operator does not hold in general and we prove the case in which it is valid.
Andrea Aglić Aljinović, Lana Horvat Dmitrović, Ana Žgaljić Keko   +2 more
doaj   +1 more source