Results 61 to 70 of about 2,570,036 (296)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

DISTINGUISHING BETWEEN SCIENCE AND SCIENTISM [PDF]

open access: yes, 2014
Issues of conflict between science and faith/religion have existed for a long time. Some of the topics that have become the source of the conflicts are: The Evolution Theory and The Big Bang Theory which are assumed to be in contra with the creation ...
Christin, Christin
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

THE INFLUENCE OF LIFE EXPECTANCY IN THE DETERMINATION OF PENSION FUND INVESTMENTS [PDF]

open access: yes, 2014
Preparating one’s retirement is important for many people, because an employee will often have no salary anymore after retiring, but his/her daily needs are still remained.
Kristiani, Farah
core  

Q-integral complete r-partite graphs

open access: yesLinear Algebra and its Applications, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zhao, Guopeng, Wang, Ligong, Li, Ke
openaire   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

ANALISIS MODEL PROBABILISTIK PUNAHNYA MUTAN PARASIT MALARIA YANG RESISTEN TERHADAP KLOROKUIN PLUS AMODIAKUIN [PDF]

open access: yes, 2014
In this paper probabilistic models are developed from a model of malaria parasite population dynamics proposed by Macdonald [1] based on Galton-Watson branching and generating Negative Binomial distribution with maximum likelihood estimation, to test a ...
Nainggolan, Jonner
core  

Some Carleman-type inequalities in ( p , q ) $(p,q)$ -calculus

open access: yesJournal of Inequalities and Applications
In this paper, we construct ( p , q ) $\left (p,q\right )$ -type Jessen’s inequality using the properties of convex functions. On this basis, we generalize the classical Carleman integral-type inequality in ( p , q ) $\left (p,q\right )$ -calculus and ...
Jiao Yu, Lin Han
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Saigo Fractional q-Differentiation Operator Involving Generalized q-Mittag–Leffler Function

open access: yesJournal of Mathematics
The purpose of this study is to obtain the images of the generalized q-analogue of Mittag–Leffler functions under the Saigo fractional q-differentiation operator, where its argument consists of a factor xζxq−μ+ξ−θ.
Mulugeta Dawud Ali, D. L. Suthar
doaj   +1 more source

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