Results 71 to 80 of about 2,570,036 (296)

Q-integral graphs with edge–degrees at most five

open access: yesDiscrete Mathematics, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Slobodan K. Simic, Zoran Stanic
openaire   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Opial inequality in q-calculus

open access: yesJournal of Inequalities and Applications, 2018
In this article we give q-analogs of the Opial inequality for q-decreasing functions. Using a closed form of the restricted q-integral (see Gauchman in Comput. Math. Appl. 47:281–300, 2004), we establish a new integral inequality of the q-Opial type.
Tatjana Z. Mirković   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Household behavior change for climate change response: an integral scan [PDF]

open access: yes, 2009
The question of how to successfully facilitate the changes needed to avoid dangerous climate change has become a critical one for researchers and practitioners.
Riedy, C
core  

On Q-spectral integral variation [PDF]

open access: yes, 2009
Let G be a graph with two non adjacent vertices and G0 the graph constructed from G by adding an edge between them. It is known that the trace of Q0 is 2 plus the trace of Q, where Q and Q0 are the signless Laplacian matrices of G and G0 respectively.
Kirkland, Steve
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Infinite families of Q-integral graphs [PDF]

open access: yes, 2010
In this article, we characterize all signless Laplacian integral graphs (here called Q-integral graphs) in the following classes: complete split graphs, multiple complete split-like graphs, extended complete split-like graphs, multiple extended split ...
de Freitas, Maria Aguieiras A.   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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