Results 231 to 240 of about 241,763 (280)

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao   +7 more
wiley   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

open access: yesAdvanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu   +6 more
wiley   +1 more source

Optimizing QoS and security in agriculture IoT deployments: A bioinspired Q-learning model with customized shards. [PDF]

open access: yesHeliyon
Sonavane SM   +6 more
europepmc   +1 more source

Quad-Q-learning

IEEE Transactions on Neural Networks, 2000
This paper develops the theory of quad-Q-learning which is a new learning algorithm that evolved from Q-learning. Quad-Q-learning is applicable to problems that can be solved by "divide and conquer" techniques. Quad-Q-learning concerns an autonomous agent that learns without supervision to act optimally to achieve specified goals.
C, Clausen, H, Wechsler
openaire   +2 more sources

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