Results 271 to 280 of about 171,350 (313)

DPImpute: A Genotype Imputation Framework for Ultra‐Low Coverage Whole‐Genome Sequencing and its Application in Genomic Selection

Advanced Science, EarlyView.
DPImpute is a two‐step pipeline that outperforms existing tools in whole‐genome SNP imputation, particularly under conditions of ultra‐low coverage sequencing, small sample sizes, and limited references. It enables precise imputation for single blastocyst cells, supporting genomic selection at the pre‐implantation stage.
Weigang Zheng, Wenlong Ma, Zhilong Chen, Chao Wang, Tao Sun, Wenjun Dong, Wenjing Zhang, Song Zhang, Zhonglin Tang, Kui Li, Yunxiang Zhao, Yuwen Liu   +11 more
wiley   +1 more source

Deviation optimal learning using greedy $Q$-aggregation

, 2012
Dong Dai, Philippe Rigollet, Tong Zhang
openalex   +1 more source

High‐Conductivity, Self‐Healing, and Adhesive Ionic Hydrogels for Health Monitoring and Human‐Machine Interactions Under Extreme Cold Conditions

Advanced Science, EarlyView.
This study presents an ionic conductive hydrogel (ICH) with excellent conductivity, self‐healing, self‐adhesion, and long‐term stability under extreme cold conditions. It shows significant potential for non‐invasive, continuous health monitoring, conformally adhering to skin without signal crosstalk, enabling real‐time, high‐fidelity signal ...
Fei Han, Shumeng Chen, Fei Wang, Mei Liu, Jiahui Li, Hao Liu, Yanshen Yang, Haoqing Zhang, Dong Liu, Rongyan He, Wentao Cao, Xiaochuan Qin, Feng Xu   +12 more
wiley   +1 more source

Expression of Continuous State and Action Spaces forQ-Learning Using Neural Networks and CMAC

, 2012
Kazuaki Yamada
openalex   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Prioritized epoch-incremental Q-learning algorithm

, 2012
Roman Zajdel
openalex   +2 more sources

CPL‐Diff: A Diffusion Model for De Novo Design of Functional Peptide Sequences with Fixed Length

Advanced Science, EarlyView.
This study presents a diffusion model for generating functional peptide sequence lengths using mask control. The model can generate antimicrobial, antifungal, and antiviral peptides with specific lengths on demand. The model learns the structure of peptides better and generates peptides with better physicochemical properties, and the model has good ...
Zhenjie Luo, Aoyun Geng, Leyi Wei, Quan Zou, Feifei Cui, Zilong Zhang   +5 more
wiley   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

Advanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang, Peng Qing, Qi Liu, Can Liu, Lei Liu, Xianyang Gan, Kun Fu, Chunmei Lan, Xinqi Zhou, Keith M. Kendrick, Benjamin Becker, Weihua Zhao   +11 more
wiley   +1 more source

Topology‐Optimized Bound States in the Continuum with High‐Q Acoustic Field Enhancement

Advanced Science, EarlyView.
This study presents a topology optimization method for acoustic metamaterials, achieving high‐Q resonances by redesigning a single unit cell within a periodic array. The design enables precise pressure confinement and energy trapping, validated through experiments.
Weibai Li, Kazem Ghabraie, Xiaodong Huang   +2 more
wiley   +1 more source