Results 41 to 50 of about 80,318 (305)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Revealing the Evolution from Q-Switching to Mode-Locking in an Erbium-Doped Fiber Laser Using Tungsten Trioxide Saturable Absorber

Photonics, 2022
Passively Q-switching and mode-locking technologies can generate short pulses with durations that differ by several orders of magnitude widely used in different applications.
Xin Tan, Ya Liu, Yongkang Zheng, Zewu Xie, Guoqing Hu   +4 more
doaj   +1 more source

Q-switched ruby laser alloying of Ohmic contacts on gallium arsenide epilayers [PDF]

, 1978
Ohmic contacts of AuGe have been produced on GaAs epilayers by laser alloying. The contacts possess morphological and electrical properties which are superior to those formed by conventional ...
Fekete, Dan, Lee, Chien-Ping, Margalit, Shlomo, Pepper, David M., Yariv, Amnon   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Nanosecond Hybrid Q-Switched Er-Doped Fiber Laser With WS₂ Saturable Absorber

IEEE Photonics Journal, 2016
We demonstrate a stable hybrid Q-switched Er-doped fiber (EDF) laser with WS2 as the saturable absorber (SA). The SA device is obtained by depositing WS2 on a tapered fiber using the pulsed laser deposition method.
Lihui Pang, Wenjun Liu, Wenlong Tian, Hainian Han, Zhiyi Wei   +4 more
doaj   +1 more source

Fast recharge circuit for q-switched lasers [PDF]

, 1973
Cavity-dumped lasers employ electrooptic-effect cell to alternately block and release laser pulse. Cell requires high-speed switching circuit that can apply and remove high voltage.
Hansen, R. L.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Q-switched, cavity-dumped, mode-locked laser [PDF]

, 1973
Continuous-wave laser can achieve higher rate of emission through Q-switching. Technique keeps Q, energy storage rating, of laser cavity at low value while ion population inversion is being built up.
Fountain, W.
core   +1 more source

Nonlinear beam self-cleaning in a coupled cavity composite laser based on multimode fiber [PDF]

, 2014
We study a coupled cavity laser configuration where a passively Q-switched Nd:YAG microchip laser is combined with an extended cavity, including a doped multimode fiber.
Aaltonen, T, Amerio, S, Amidei, D, Anastassov, A, Annovi, A, Antos, J, Apollinari, G, Appel, JA, Arisawa, T, Artikov, A, Asaadi, J, Ashmanskas, W, Auerbach, B, Aurisano, A, Azfar, F, Badgett, W, Bae, T, Barbaro-Galtieri, A, Barnes, VE, Barnett, BA, Barria, P, Bartos, P, Bauce, M, Bedeschi, F, Behari, S, Bellettini, G, Bellinger, J, Benjamin, D, Beretvas, A, Bhatti, A, Bland, KR, Blumenfeld, B, Bocci, A, Bodek, A, Bortoletto, D, Boudreau, J, Boveia, A, Brigliadori, L, Bromberg, C, Brucken, E, Budagov, J, Budd, HS, Burkett, K, Busetto, G, Bussey, P, Butti, P, Buzatu, A, Calamba, A, Camarda, S, Campanelli, M, Canelli, F, Carls, B, Carlsmith, D, Carosi, R, Carrillo, S, Casal, B, Casarsa, M, Castro, A, Catastini, P, Cauz, D, Cavaliere, V, CDF Collaboration, Cerri, A, Cerrito, L, Chen, YC, Chertok, M, Chiarelli, G, Chlachidze, G, Cho, K, Chokheli, D, Clark, A, Clarke, C, Convery, ME, Conway, J, Corbo, M, Cordelli, M, Cox, CA, Cox, DJ, Cremonesi, M, Cruz, D, Cuevas, J, Culbertson, R, d'Ascenzo, N, D'Errico, M, D'Onofrio, M, da Costa, JG, Datta, M, de Barbaro, P, Demortier, L, Deninno, M, Denis, RS, Devoto, F, Di Canto, A, Di Ruzza, B, Dittmann, JR, Donati, S, Dorigo, M, Driutti, A, Ebina, K, Edgar, R, Elagin, A, Erbacher, R, Errede, S, Esham, B, Farrington, S, Fernandez, IR, Field, R, Flanagan, G, Forrest, R, Franklin, M, Freeman, JC, Frisch, H, Funakoshi, Y, Galloni, C, Garfinkel, AF, Garosi, P, Gerberich, H, Gerchtein, E, Giagu, S, Giakoumopoulou, V, Gibson, K, Ginsburg, CM, Giokaris, N, Giromini, P, Glagolev, V, Glenzinski, D, Gold, M, Goldin, D, Golossanov, A, Gomez, G, Gomez-Ceballos, G, Goncharov, M, Gorelov, I, Goshaw, AT, Goulianos, K, Gramellini, E, Grosso-Pilcher, C, Group, RC, Hahn, SR, Han, JY, Happacher, F, Hara, K, Hare, M, Harr, RF, Harrington-Taber, T, Hatakeyama, K, Hays, C, Heinrich, J, Herndon, M, Hocker, A, Hong, Z, Hopkins, W, Hou, S, Hughes, RE, Husemann, U, Hussein, M, Huston, J, III, WWC, Introzzi, G, Iori, M, Ivanov, A, James, E, Jang, D, Jayatilaka, B, Jeon, EJ, Jindariani, S, Jones, M, Joo, KK, Jun, SY, Junk, TR, Kambeitz, M, Kamon, T, Karchin, PE, Kasmi, A, Kato, Y, Ketchum, W, Keung, J, Kilminster, B, Kim, DH, Kim, HS, Kim, JE, Kim, MJ, Kim, SB, Kim, SH, Kim, YJ, Kim, YK, Kimura, N, Kirby, M, Knoepfel, K, Kondo, K, Kong, DJ, Konigsberg, J, Kotwal, AV, Kreps, M, Kroll, J, Kruse, M, Kuhr, T, Kurata, M, Laasanen, AT, Lammel, S, Lancaster, M, Lannon, K, Latino, G, Lee, HS, Lee, JS, Leo, S, Leone, S, Lewis, JD, Limosani, A, Lipeles, E, Lister, A, Liu, H, Liu, Q, Liu, T, Lockwitz, S, Loginov, A, Lopez, OG, Luca, A, Lucchesi, D, Lueck, J, Lujan, P, Lukens, P, Lungu, G, Lys, J, Lysak, R, Madrak, R, Maestro, P, Malik, S, Manca, G, Manousakis-Katsikakis, A, Marchese, L, Margaroli, F, Marino, P, Matera, K, Mattson, ME, Mazzacane, A, Mazzanti, P, McNulty, R, Mehta, A, Mehtala, P, Mesropian, C, Miao, T, Mietlicki, D, Mitra, A, Miyake, H, Moed, S, Moggi, N, Moon, CS, Moore, R, Morello, MJ, Mukherjee, A, Muller, T, Murat, P, Mussini, M, Nachtman, J, Nagai, Y, Naganoma, J, Nakano, I, Napier, A, Nett, J, Neu, C, Nigmanov, T, Nodulman, L, Noh, SY, Norniella, O, Oakes, L, Oh, SH, Oh, YD, Oksuzian, I, Okusawa, T, Orava, R, Ortolan, L, Pagliarone, C, Palencia, E, Palni, P, Papadimitriou, V, Parker, W, Pauletta, G, Paulini, M, Paus, C, Phillips, TJ, Pianori, E, Pilot, J, Pitts, K, Plager, C, Pondrom, L, Poprocki, S, Potamianos, K, Pranko, A, Prokoshin, F, Ptohos, F, Punzi, G, Ramos, JPF, Renton, P, Rescigno, M, Rimondi, F, Ristori, L, Robson, A, Rodriguez, T, Rolli, S, Ronzani, M, Roser, R, Rosner, JL, Ruffini, F, Ruiz, A, Russ, J, Rusu, V, Sakumoto, WK, Sakurai, Y, Santi, L, Sato, K, Saveliev, V, Savoy-Navarro, A, Schlabach, P, Schmidt, EE, Schwarz, T, Scodellaro, L, Scuri, F, Seidel, S, Seiya, Y, Semenov, A, Sforza, F, Shalhout, SZ, Shears, T, Shepard, PF, Shimojima, M, Shochet, M, Shreyber-Tecker, I, Simonenko, A, Sliwa, K, Smith, JR, Snider, FD, Song, H, Sorin, V, Stancari, M, Stentz, D, Strologas, J, Sudo, Y, Sukhanov, A, Suslov, I, Takemasa, K, Takeuchi, Y, Tang, J, Tecchio, M, Teng, PK, Thom, J, Thomson, E, Thukral, V, Toback, D, Tokar, S, Tollefson, K, Tomura, T, Tonelli, D, Torre, S, Torretta, D, Totaro, P, Trovato, M, Ukegawa, F, Uozumi, S, Velev, G, Vellidis, C, Vernieri, C, Vidal, M, Vilar, R, Vizan, J, Vogel, M, Volpi, G, Vzquez, F, Wagner, P, Wallny, R, Wang, SM, Waters, D, Whiteson, D, Wicklund, AB, Wilbur, S, Williams, HH, Wilson, JS, Wilson, P, Winer, BL, Wittich, P, Wolbers, S, Wolfe, H, Wright, T, Wu, X, Wu, Z, Yamamoto, K, Yamato, D, Yang, T, Yang, UK, Yang, YC, Yao, W-M, Yeh, GP, Yi, K, Yoh, J, Yorita, K, Yoshida, T, Yu, GB, Yu, I, Zanetti, AM, Zeng, Y, Zhou, C, Zucchellia, S   +401 more
core   +7 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source