Results 221 to 230 of about 936,931 (309)

Quantitative HILIC-Q-TOF-MS Analysis of Glycosaminoglycans and Non-reducing End Carbohydrate Biomarkers via Glycan Reductive Isotopic Labeling. [PDF]

Anal Chem
Basu A, Archer-Hartmann S, Chopra P, Taherzadeh Ghahfarrokhi M, Dong X, Patel NG, Zhang Y, Choudhury B, Funato K, Yellajoshyula D, Boons GJ, Azadi P, Weiss RJ.   +12 more
europepmc   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

UPLC-Q-TOF/MS, network pharmacology, molecular docking, and experimental validation to explore the mechanisms of toad clothing on rheumatoid arthritis. [PDF]

Sci Rep
Wang T, Xia H, Zhu J, Yu M, Zhang Z, Lu J, Zhou W, Xu J.   +7 more
europepmc   +1 more source

Fluorogenic Sydnones for Bioorthogonal Labeling of DNA

Chemistry – A European Journal, EarlyView.
Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller, Hans‐Achim Wagenknecht   +1 more
wiley   +1 more source

Nutritional valorization of Manila tamarind accessions through antioxidant analysis and UHPLC-Q-TOF-MS-based metabolomic profiling. [PDF]

Front Nutr
Yadav A, Jha S, Choudhary G, Ram A, Kumar R, Kumar N, Anuragi H, Garg S, Kumar A, Singh P, Dwivedi RP, Arunachalam A, Jinger D.   +12 more
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Exploring the Potential Mechanism of Liupao Tea Using UPLC-Q-TOF/MS and Network Pharmacology. [PDF]

Pharmaceuticals (Basel)
Jia F, Yang Q, Yao L, Liu Y, Deng J, Leng J, Fan L, Hao E.   +7 more
europepmc   +1 more source

Interfacial and Ligand Dual Engineering Toward Energy‐Saving Hydrogen Production Coupled with Sulfion Degradation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Using a coordinated regulation strategy of interface and ligand, we developed a nickel cobalt sulfide/carboxylate ligand‐modified nickel cobalt hydroxide composite (NiCo‐S/NiCo‐OH‐CL) with abundant heterointerfaces. Owing to the porous network, sulfur‐repellent hydrophilic surface, and dual electronic structure regulation, the coupled electrolysis ...
Jinghui Guo, Min Zhou, Yang Shen, Guo Yu, Qijun Wang, Heyan Yu, Leyuan Wang, Feng Wang, Wei Yang, Hairen Wang, Yu Ding, Yan Zhao, Zhaoyang Wang   +12 more
wiley   +1 more source

Characterization and Anti-Allergic Mechanisms of Bioactive Compounds in a Traditional Chinese Medicine Prescription Using UHPLC-Q-TOF-MS/MS, Network Pharmacology and Computational Simulations. [PDF]

Pharmaceuticals (Basel)
Hong L, Qin Y, Ip C, Xu W, Zeng H, Duan X, Wang J, Zhao J, Wang Q, Li S.   +9 more
europepmc   +1 more source