Results 31 to 40 of about 221,506 (173)

Letter. Research evaluation entities cause a shift of publication to Q1 journals

, 2020
In Scopus there are four times more documents in first-quartile publications than in fourth-quartile ones. Publishers intend to adjust the editorial supply to the demand from authors, which seems to focus primarily on Q1 publications.
Félix De-Moya-Anegón
semanticscholar   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Protocol for generation of and high-throughput drug testing with patient-derived colorectal cancer organoids

STAR Protocols
Summary: Drug sensitivity testing of patient-derived tumor organoids (PDTOs) is a promising tool for personalizing cancer treatment. Here, we present a protocol for generation of and high-throughput drug testing with PDTOs. We describe detailed steps for
Tao Tan, Dmitri Mouradov, Peter Gibbs, Oliver M. Sieber   +3 more
doaj   +1 more source

Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang, Zongtai Liu, Yirong Sun, Changfeng Fu, Jianxun Ding   +4 more
wiley   +1 more source

Protocol to analyze immune cells in the tumor microenvironment by transcriptome using machine learning

STAR Protocols
Summary: Immunotherapy is a promising strategy to treat cancer. Here, we present a protocol for analyzing the transcriptome-based phenotypic alterations and immune cell infiltration in the tumor microenvironment.
Yunxi Liao, Ziyan Rao, Shaodong Huang, Dongyu Zhao   +3 more
doaj   +1 more source

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Rockburst prediction based on data preprocessing and hyperband‐RNN‐DNN

Deep Underground Science and Engineering, EarlyView.
A data preprocessing workflow is proposed to address challenges in rockburst data analysis. Coupled algorithms preprocess the data set, and hyperband optimization is used to enhance RNN performance. Results show that preprocessing improves accuracy, while dense layers enhance model stability and prediction performance.
Yong Fan, Chenxi Yin, Guangdong Yang, Shengyong Ding, Bin Tian   +4 more
wiley   +1 more source

MEASURING TRANSIT SIGNAL RECOVERY IN THE KEPLER PIPELINE. III. COMPLETENESS OF THE Q1–Q17 DR24 PLANET CANDIDATE CATALOG WITH IMPORTANT CAVEATS FOR OCCURRENCE RATE CALCULATIONS [PDF]

, 2016
With each new version of the Kepler pipeline and resulting planet candidate catalog, an updated measurement of the underlying planet population can only be recovered with a corresponding measurement of the Kepler pipeline detection efficiency.
J. Christiansen, B. Clarke, C. Burke, J. Jenkins, S. Bryson, J. Coughlin, F. Mullally, S. Thompson, J. Twicken, N. Batalha, M. Haas, J. Catanzarite, Jennifer Campbell, A. K. Uddin, Khadeejah A. Zamudio, Jeffrey C. Smith, C. Henze   +16 more
semanticscholar   +1 more source

Pre‐ and post‐diagnostic meat intake in relation to risk of recurrence and mortality among individuals with stage I–III colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Processed meat and unprocessed red meat intakes are associated with increased colorectal cancer risk. However, evidence on their associations with mortality after colorectal cancer diagnosis is inconsistent. This study examined associations between three meat types, including unprocessed poultry, and the risk of recurrence and all‐cause ...
Anne‐Sophie van Lanen, Dieuwertje E. Kok, Evertine Wesselink, Jeroen W. G. Derksen, Anne M. May, Karel C. Smit, Miriam Koopman, Johannes H. W. de Wilt, Ellen Kampman, Fränzel J. B. van Duijnhoven, on behalf of the COLON and PLCRC studies, Hester van Cruijsen, Jan Willem T. Dekker, Henk K. van Halteren, Johan J.B. Janssen, Maartje Los, Anandi H. W. Schiphorst, Dirkje W. Sommeijer, Dirk J. A. Sonneveld, Mark P. S. Sie, Maarten Vermaas   +20 more
wiley   +1 more source

Chemical characterization and source apportionment of rainwater in Cuieiras Biological Reserve, central Amazon, Brazil [PDF]

Acta Amazonica
The Amazon rainforest plays a crucial role in the global climate system, acting as a major carbon sink and influencing regional and global weather patterns.
Alex Ruben Huaman DE LA CRUZ, Marcos Felipe de Souza PEDREIRA, José Marcus GODOY, Paulo ARTAXO, Adriana GIODA   +4 more
doaj   +1 more source