Results 71 to 80 of about 221,506 (173)

The Invisible Costs of Cancer Treatment: Quantifying Non‐Medical Economic Consequences for Cancer Survivors Undergoing Systemic and Radiation Therapies

Cancer Medicine, Volume 14, Issue 20, October 2025.
ABSTRACT Background The non‐medical economic consequences of cancer on individuals and families in low‐ and middle‐income countries, including Bangladesh, remain poorly quantified. This study measures the non‐medical economic consequences of cancer survivors and their families, including sacrifices in essential family consumption, social participation ...
Md. Shahjalal, Padam Kanta Dahal, Md. Parvez Mosharaf, Yifu Chen, Mohoua Azmary, Edward Christopher Dee, Khorshed Alam, Rashidul Alam Mahumud   +7 more
wiley   +1 more source

Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions

MedComm, Volume 6, Issue 10, October 2025.
PROTACs are reshaping drug discovery through targeted protein degradation. Clinical programs now extend to prostate, breast, lung, hematologic, and solid tumors, with key targets including AR, ER, BTK, STAT3, Bcl‐xL, BRD9, Kras, and so on. These degraders overcome resistance, broaden therapeutic scope, and provide solutions for “undruggable” proteins ...
Gang Fan, Shilin Chen, Qingping Zhang, Na Yu, Ziyang Shen, Zhaoji Liu, Weiming Guo, Zhihan Tang, Jing Yang, Miao Liu   +9 more
wiley   +1 more source

Predictive Value of Bone Metabolism Marker PINP in the Risk of Diabetic Retinopathy: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity
Guanhua Chen,1,2,* Yuan Zhang,1,2,* Weimin Wang,2,3,* Yali Jing1,2,* 1Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing University of ...
Chen G, Zhang Y, Wang W, Jing Y
doaj  

6PPD-quinone affects the photosynthetic carbon fixation in cyanobacteria by extracting photosynthetic electrons

The Innovation
Photosynthetic carbon fixation by cyanobacteria plays a pivotal role in the global carbon cycle but is threatened by environmental pollutants. To date, the impact of quinones, with electron shuttling properties, on cyanobacterial photosynthesis is ...
Xiuqi You, Ximin Chen, Yi Jiang, Huan Chen, Juan Liu, Zhen Wu, Weiling Sun, Jinren Ni   +7 more
doaj   +1 more source

Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide*

Journal of Biological Chemistry, 2016
Diallyl trisulfide (DATS), a metabolic byproduct of garlic, is known to inhibit the growth of breast cancer cells in vitro and in vivo. This study demonstrates that DATS targets breast cancer stem cells (bCSC).
Su-Hyeong Kim, C. Kaschula, N. Priedigkeit, Adrian V. Lee, Shivendra V. Singh   +4 more
semanticscholar   +1 more source

Evolution of Amazonian biodiversity: A review [PDF]

Acta Amazonica
Amazonia (defined herein as the Amazon basin) is home to the greatest concentration of biodiversity on Earth, providing unique genetic resources and ecological functions that contribute to ecosystem services globally. The lengthy and complex evolutionary
Juan M. GUAYASAMIN, Camila C. RIBAS, Ana C. CARNAVAL, Juan D. CARRILLO, Carina HOORN, Lúcia G. LOHMANN, Douglas RIFF, Carmen ULLOA ULLOA, James S. ALBERT   +8 more
doaj   +1 more source

Mucosal, Cellular, and Humoral Immune Responses Induced by Different Live Infectious Bronchitis Virus Vaccination Regimes and Protection Conferred against Infectious Bronchitis Virus Q1 Strain

Clinical and Vaccine Immunology, 2015
The objectives of the present study were to assess the mucosal, cellular, and humoral immune responses induced by two different infectious bronchitis virus (IBV) vaccination regimes and their efficacy against challenge by a variant IBV Q1.
R. Chhabra, A. Forrester, S. Lemiere, F. Awad, J. Chantrey, K. Ganapathy   +5 more
semanticscholar   +1 more source

The GFDL‐CM4X Climate Model Hierarchy, Part I: Model Description and Thermal Properties

Journal of Advances in Modeling Earth Systems, Volume 17, Issue 10, October 2025.
Abstract We present the GFDL‐CM4X (Geophysical Fluid Dynamics Laboratory Climate Model version 4X) coupled climate model hierarchy. The primary application for CM4X is to investigate ocean and sea ice physics as part of a realistic coupled Earth climate model.
Stephen M. Griffies, Alistair Adcroft, Rebecca L. Beadling, Mitchell Bushuk, Chiung‐Yin Chang, Henri F. Drake, Raphael Dussin, Robert W. Hallberg, William J. Hurlin, Hemant Khatri, John P. Krasting, Matthew Lobo, Graeme A. MacGilchrist, Brandon G. Reichl, Aakash Sane, Olga Sergienko, Maike Sonnewald, Jacob M. Steinberg, Jan‐Erik Tesdal, Matthew Thomas, Katherine E. Turner, Marshall L. Ward, Michael Winton, Niki Zadeh, Laure Zanna, Rong Zhang, Wenda Zhang, Ming Zhao   +27 more
wiley   +1 more source

The importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation

British Journal of Haematology, Volume 207, Issue 4, Page 1517-1528, October 2025.
In oncological patients SIR measures like the mGPS have great impact on prognosis at starting therapy. We recorded at admission for allo‐HCT the mGPS in 2201 patients: score 0 CRP/sALB normal; score 1 CRP >10mg/dl; score 2 CRP >10mg/dl + sALB <35g/L. Multivariate analysis revealed a significant impact with a low GPS score for OS: mGPS 1 vs.
Hartmut Bertz, Jörg Sahlmann, Donald C. McMillan, Claudia Wehr, Jesus Duque‐Afonso, Kristina Maas‐Bauer, Ralph Wäsch, Julia Nikolaychuk, Christine Greil, Jann Arends, Jürgen Finke, Robert Zeiser   +11 more
wiley   +1 more source

The association between HIV drug resistance testing, viral suppression and mortality in Ontario: a retrospective cohort study

HIV Medicine, Volume 26, Issue 10, Page 1550-1561, October 2025.
Abstract Background Drug resistance compromises the effectiveness of antiretroviral therapy (ART). Resistance testing prior to initiating therapy is recommended in guidelines in many high‐income countries, and it has been shown to improve outcomes after first‐line ART regimen failure. There is limited evidence on its role in treatment‐naïve individuals.
Lawrence Mbuagbaw, Carmen H. Logie, Lehana Thabane, Fiona Smaill, Marek Smieja, Ann N. Burchell, Beth Rachlis, Jean Eric Tarride, Abigail E. Kroch, Tony Mazzulli, Elizabeth Alvarez, Francis Nguyen, Richard Perez, Cristian Garcia, Jessyca Matos Silva, Hsien Seow   +15 more
wiley   +1 more source