Results 11 to 20 of about 1,672 (130)

Fundamental Challenges, Physical Implementations, and Integration Strategies for Ising Machines in Large‐Scale Optimization Tasks

Advanced Electronic Materials, EarlyView.
Ising machines are emerging as specialized hardware solvers for computationally hard optimization problems. This review examines five major platforms—digital CMOS, analog CMOS, emerging devices, coherent optics, and quantum systems—highlighting physics‐rooted advantages and shared bottlenecks in scalability and connectivity.
Hyunjun Lee, Joon Pyo Kim, Sanghyeon Kim
wiley   +1 more source

Talk to Your Data: An Agentic Artificial Intelligence‐Driven Decision‐Support Framework for Prosumer Energy Optimization and Recommendations

Advanced Intelligent Systems, EarlyView.
An agentic AI‐driven decision‐support framework for prosumers is proposed, integrating PV generation, load profiling, and multihorizon optimization within a four‐agent architecture. The approach significantly reduces grid dependence, enhances self‐sufficiency and prevents system oversizing.
Adela BÂRA, Simona‐Vasilica OPREA
wiley   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Inventory Replenishment and Transshipment for Distributed Autologous Cell Therapy Manufacturing Networks

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Autologous cell therapy (AuCT) manufacturing networks must balance two competing objectives: reducing cost and improving patient access to time‐sensitive therapy. This study compares three AuCT manufacturing network designs: a centralized network with a single manufacturing facility, a coordinated point‐of‐care (POC) network in which POCs can ...
Zhaowei Li, Chelsea C. White III, Kan Wang, Ben Wang   +3 more
wiley   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Rock mechanical properties under reconstructed deep in situ thermo–hydro–mechanical conditions: Implications for CO₂‐related injection scenarios

Deep Underground Science and Engineering, EarlyView.
The graphical abstract illustrates a reconstructed in situ thermo‐hydro‐mechanical (THM) framework in which porosity serves as the central variable linking stress, pore pressure, and temperature to evolving mechanical properties of rocks. Under burial conditions, in situ stress, pore pressure, and temperature jointly govern volumetric strain and ...
Mingyuan Lu, Jun Wang, Zixiong Qi, Ruixuan Chen, Hongtao Wang, Hongwei Zhou   +5 more
wiley   +1 more source

Explainable hybrid stacking ensemble method for hard rock pillar stability prediction and engineering applications

Deep Underground Science and Engineering, EarlyView.
This research proposes an interpretable hybrid stacking ensemble framework, optimized by the Sparrow Search Algorithm, to enhance hard rock pillar stability prediction. By integrating six machine learning models—k‐nearest neighbors, support vector machines, random forests, Gradient Boosting Decision Tree, eXtreme Gradient Boosting, and Light Gradient ...
Ning Wang, Guoyan Zhao, Meng Wang, Taraka Pattela   +3 more
wiley   +1 more source

Numerical Analysis and Optimization of a Continuous‐Flow pH‐TRC for Steady‐State Low‐Grade Waste Heat Recovery

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A steady‐state numerical model is established for a continuous‐flow pH‐TRC for low‐grade waste heat recovery. Based on carbonate and bicarbonate electrolytes, the influences of operating conditions and electrode structure on pH‐driven power generation are clarified.
Jinpeng Hu, Haotong Cai, Hao Yu, Runchen Zhao, Zhongxin Chen, Meng Ni, Shuaibin Wan, Dongxu Ji   +7 more
wiley   +1 more source

Streamlining Hospital Planning: A User‐Friendly Decision Support Tool for Enhanced Healthcare Delivery

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Healthcare providers worldwide face challenges in maintaining a delicate balance between rising demand and limited resources. Decision‐makers often struggle with planning and implementing new services, leading to costly consequences and hindering efficiency, patient outcomes, and staff well‐being. Current systems lack a comprehensive modelling
Eren Demir
wiley   +1 more source