Results 111 to 120 of about 39,340 (291)

Issue Construals and Corporate Water Stewardship

Business Strategy and the Environment, EarlyView.
ABSTRACT In the face of mounting environmental and social pressures, the importance of responsible corporate water stewardship (CWS) should be evident, yet not all businesses are taking water management issues seriously. The aim of this study is to explore why differences in CWS persist, especially within industries facing similar resource challenges ...
Daina Mazutis, Mohamed Chelli, Sharon OSullivan, Katherine Hanly   +3 more
wiley   +1 more source

Combination tumor‐treating fields treatment for patients with metastatic non‐small cell lung cancer: A cost‐effectiveness analysis

Cancer Medicine
Background Tumor‐treating field (TTFields) was a novel antitumor therapy that provided significant survival for previously treated metastatic non‐small cell lung cancer (mNSCLC).
Kun Liu, Youwen Zhu, Hong Zhu, Manting Zeng   +3 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Polymer Molecular Interface Engineering—Enhanced Cu‐Based Catalysts for the CO2 Electroreduction Reaction

Carbon Energy, EarlyView.
This review highlights polymer‐mediated interfacial engineering strategies for Cu‐based electrocatalysts toward enhanced CO2RR, including steering the electronic structure of Cu, enhancing CO2 adsorption and activation, regulating the reaction microenvironment, constructing a molecular protective layer, and stabilizing the key intermediate.
Haoquan Peng, Xinyi Tan, Yalin Xie, Jianren Wang, Zhourong Xiao, Ailing Song, Desong Wang, Liming Dai   +7 more
wiley   +1 more source

Reverse Engineering and Performance Evaluation of a Pump Impeller Fabricated With Additive Manufacturing

Chemie Ingenieur Technik, EarlyView.
This study explores the process chain for reverse engineering and additive manufacturing of a water pump impeller in a process plant. Key aspects include digital twin creation, CAD redesign, material certification, Hirtisation postprocessing, and performance testing. Insights highlight iterative design for improved precision and reliability.
Michael Stadler, Kati Schatz, Sebastian Rehfeldt, Harald Klein   +3 more
wiley   +1 more source

Cost-effectiveness analysis of intensive and emerging rehabilitation therapies in children with cerebral palsy: an observational cohort study using real-world evidence and microsimulation modelling

Health Economics Review
Objective To evaluate the short- and long-term cost-effectiveness of integrating Intensive and Emerging Rehabilitation Therapies into standard care for children with cerebral palsy (CP), compared to standard care alone, through a hybrid approach ...
Diana Marcela Nova-Díaz, Sergio Aguilera-Albesa, Eduardo Sánchez-Iriso   +2 more
doaj   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Unprincipled QALYs: A Response to Cubbon

, 1991
Defenders of QALYs persistently and perversely argue from the unexceptionable premise that QALYs (years of quality life-time) are a "basic human need in all times and places" to the unjustified and dangerous conclusions that they are a defensible and ...
Harris, John
core   +1 more source

A Robust Computational Workflow Utilizing Generalized Least Squares (GLS) and Generalized Estimating Equations (GEE‐GLM) for Longitudinal Flow Cytometry Maturation Data Analysis

Cytometry Part A, EarlyView.
ABSTRACT Routinely used statistical hypothesis tests are often inadequate for longitudinal flow cytometry data, necessitating more sophisticated modeling approaches. Analyzing dynamic biomarker expression across hematopoietic maturation presents several analytical challenges, notably nonlinearity, serial correlation between subsequent stages, and ...
Sixuan Joanna Wang, Ruben Deneer, Tom Schoenmakers, Stefan G. C. Mestrum, Yvonne M. C. Henskens, Otto Bekers, Anton H. N. Hopman, Frans C. S. Ramaekers, Mathie P. G. Leers   +8 more
wiley   +1 more source