Results 101 to 110 of about 6,391 (215)

Bacteriophage RNA polymerases: catalysts for mRNA vaccines and therapeutics

Frontiers in Molecular Biosciences
Decades of research on bacteriophage-derived RNA polymerases (RNAPs) were vital for synthesizing mRNA using the in vitro transcription (IVT) reaction for vaccines during the COVID-19 pandemic.
Adithya Nair, Zoltán Kis, Zoltán Kis
doaj   +1 more source

HOLISTIC APPLICATION OF QUALITY BY DESIGN (QbD) FOR PHARMA PRODUCT DEVELOPMENT EXCELLENCE AND REGULATORY COMPLIANCE [PDF]

The realm of optimizing the drug formulations has gained significant momentum towards more systematic approach of “Quality by Design (QbD)” based strategies employing “Design of Experiments (DoE)” from the erstwhile traditional short-gun approach of ...
Jain, Atul, Singh, Bhupinder, Sharma, Gajanand, Beg, Sarwar, Negi, Poonam   +4 more
core   +1 more source

Performance Analysis of DAG-Based Blockchain Systems Based on Markovian Arrival Process

IEEE Access
The Direct Acyclic Graph (DAG)-based blockchain offers impressive scalability and finds applications across various sectors, notably the Internet of Things (IoT) industry. Within this domain, IOTA has been purpose-built for IoT. This article analyzes the
Xing-Shuo Song, Shi-Yong Li
doaj   +1 more source

Triangular M/G/1-type an tree-like QBD Markov chains

, 2011
In applying matrix-analytic methods to M/G/1-type and tree-like QBD Markov chains, it is crucial to determine the solution to a (set of) nonlinear matrix equation(s). This is usually done via iterative methods.
Leeuwaarden, JSH Johan van, Van Houdt, B, Van Houdt, B., Leeuwaarden, van, J.S.H.   +3 more
core   +1 more source

Application of quality by design principles in topical semisolid formulations development: a systematic review of CQA, DoE, and control strategies

AAPS Open
Topical semisolid formulations such as creams, ointments, and gels play a critical role in dermatological therapy by delivering drugs locally while minimizing systemic exposure.
Yesuneh Tefera Mekasha, Melaku Getahun Feleke, Yousuf Mohammed   +2 more
doaj   +1 more source

A REVIEW ON QUALITY BY DESIGN APPROACH (QBD) AND IT’S BENEFITS

The newest approach in pharmaceutical production linked to quality is called Quality by Design (QbD). To guarantee that premium-grade pharmaceuticals are produced, Pharmaceutical Quality by Design, or QbD, is discussed in this article.
Sai, G. Vedavathi, Krishna, Ambati Vamsi, Venkatesh, Kannedari, Mounika, Paradeshi   +3 more
core   +1 more source

Lower order moments of inter-transition times in the stationary QBD process

, 2000
The epochs in which successive increases-or decreases-in the levels of a quasi birth-and-death process QBD process occur are of special interest. In queueing models they usually correspond to the times of successive increments or decrements.
Neuts, Marcel, Andersen, Allan T., Nielsen, Bo Friis   +2 more
core  

Pilot Design of Formulation Containing Curcumin and Ginger with Quality Based Design (QbD) Approach

Se realizó el diseño piloto de una formulación de curcumina y jengibre, aplicando la metodología de calidad basada en diseño (QbD), desarrollada con excipientes que permiten su aplicación en un jarabe libre de sacarosa como posible coadyuvante para ...
Mejía Gálvez, Marco Antonio, Cortez Martínez, César Ricardo, Abud González , Monserratt, Cortez Alvarez, César Ricardo, Aguilar Pacheco, Rogelio Alberto, Casasola Jiménez, María Fernanda, Palacios Magaña, Claudia Veronica   +6 more
core   +1 more source

Generation and Analysis of Algorithms for the Study of QBDs

TecnoLógicas, 2013
The analysis and characterization of telecommunication systems generally is performed using stochastic models, this paper presents two algorithms for the analysis of quasi birth and death (QBDs), these are implemented on two types of queues PH/PH/1 and M/M/1, showing the results of these and comparing their execution times and error results.
Ricardo C. Goméz-Vargas, Mónica Espinoza-Buitrago   +1 more
openaire   +1 more source

Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats

Drug Design, Development and Therapy, 2018
Qi Zhang,1 Jing Nie,2 Su-Juan Chen,2 Qiang Li2 1Department of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350122, China; 2School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
Zhang Q, Nie J, Chen S, Li Q
doaj