Results 11 to 20 of about 51,608 (100)

Vx-809, a CFTR Corrector, Acts through a General Mechanism of Protein Folding and on the Inflammatory Process

International Journal of Molecular Sciences, 2023
Correct protein folding is the basis of cellular well-being; thus, accumulation of misfolded proteins within the endoplasmic reticulum (ER) leads to an imbalance of homeostasis that causes stress to the ER.
M. Pecoraro, Adele Serra, M. Pascale, S. Franceschelli   +3 more
semanticscholar   +1 more source

Long-term Safety of Growth Hormone in Adults With Growth Hormone Deficiency: Overview of 15 809 GH-Treated Patients

Journal of Clinical Endocrinology and Metabolism, 2022
Context Data on long-term safety of growth hormone (GH) replacement in adults with GH deficiency (GHD) are needed. Objective We aimed to evaluate the safety of GH in the full KIMS (Pfizer International Metabolic Database) cohort.
G. Johannsson, P. Touraine, U. Feldt-Rasmussen, A. Picó, G. Vila, A. Mattsson, M. Carlsson, M. Korbonits, A. V. van Beek, M. Wajnrajch, R. Gomez, K. Yuen   +11 more
semanticscholar   +1 more source

Cytogenetic abnormalities in essential thrombocythemia: Clinical and molecular correlates and prognostic relevance in 809 informative cases

Blood Cancer Journal, 2022
Cytogenetic studies among 809 consecutive patients with essential thrombocythemia (ET; median age 59 years; 65% females) revealed normal karyotype in 754 (93%), loss of chromosome Y only (-Y) in 16 (2%), and abnormalities other than -Y in 39 (4.8%), the ...
N. Gangat, Yamna Jadoon, Natasha Szuber, C. Hanson, A. Wolanskyj-Spinner, R. Ketterling, A. Pardanani, A. Tefferi   +7 more
semanticscholar   +1 more source

CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium

Cells, 2022
Background: Cystic Fibrosis (CF) is a genetic disorder affecting around 1 in every 3000 newborns. In the most common mutation, F508del, the defective anion channel, CFTR, is prevented from reaching the plasma membrane (PM) by the quality check control of
Clarissa Braccia, J. Christopher, Oliver M. Crook, L. Breckels, R. Queiroz, Nara Liessi, Valeria Tomati, V. Capurro, T. Bandiera, Simona Baldassari, N. Pedemonte, K. Lilley, A. Armirotti   +12 more
semanticscholar   +1 more source

Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays

Pharmaceuticals, 2022
Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role is chloride’s mobilization in the epithelial cells of various ...
A. Parodi, Giada Righetti, E. Pesce, A. Salis, Valeria Tomati, C. Pastorino, B. Tasso, M. Benvenuti, G. Damonte, N. Pedemonte, E. Cichero, E. Millo   +11 more
semanticscholar   +1 more source

Aroma and terpenoid profile of Chardonnay clone 809: from berry to sparkling wine

OENO One, 2022
Clone selection is a viticultural practice applied to evaluate the behaviour and agronomic and flavour characteristics of a material in a determined environment to obtain wines with different aromatic attributes.
N. Bernardo, A. Oliveira, E. Purgatto, Francisco M. De Medeiros Câmara, Isabela Peregrino, Murillo de Albuquerque Regina, R. V. da Mota   +6 more
semanticscholar   +1 more source

VX‐809 mitigates disease in a mouse model of autosomal dominant polycystic kidney disease bearing the R3277C human mutation

The FASEB Journal, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is associated with the formation of renal cysts. We have devised a therapeutic approach, based on reversing the cyst phenotype from secretion to absorption by using VX‐809, a modulator of the cystic ...
M. Yanda, L. Cebotaru
semanticscholar   +1 more source

Effects of Micro-Tab on the Lift Enhancement of Airfoil S-809 with Trailing-Edge Flap

Processes, 2021
Recently, the Trailing-Edge Flap with Micro-Tab (TEF with Micro-Tab) has been exploited to enhance the performance of wind turbine blades. Moreover, it can also be used to generate more lift and delay the onset of stall.
Jianjun Ye, S. Salem, Juan Wang, Yiwen Wang, Zonggang Du, Wen Wang   +5 more
semanticscholar   +1 more source

Human Papillomavirus Vaccination: ACOG Committee Opinion, Number 809.

Obstetrics and Gynecology, 2020
Human papillomavirus (HPV) causes significant morbidity and mortality in women and men. The HPV vaccine significantly reduces the incidence of anogenital cancer and genital warts in women and in men.

semanticscholar   +1 more source

Geological and geochemical investigations on the eastern Trans-Mexican Volcanic Belt

Geofísica Internacional, 1985
Este trabajo informa sobre investigaciones geoquímicas y geológicas de la sección este del Cinturón Volcánico Transmexicano (TMVB}.Como resultado de nuestro trabajo, nosotros preferimos considerar que el eje neovolcánico termina en la costa del Golfo de ...
J. F. W. Negendank, R. Emmermann, R. Krawczyk, F. Mooser, H. Tobschall, D. J. Werle   +5 more
doaj   +1 more source