Results 61 to 70 of about 43,023 (70)

Revertants, Low Temperature, and Correctors Reveal the Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction

Chemistry and Biology, 2013
Carlos M Farinha, Marisa Sousa, Mónica Roxo-Rosa   +2 more
exaly  

High-Content Surface and Total Expression siRNA Kinase Library Screen with VX-809 Treatment Reveals Kinase Targets that Enhance F508del-CFTR Rescue

Molecular Pharmaceutics, 2018
Lydia A Perkins, Frederick Mun, Marcel P Bruchez   +2 more
exaly  

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

Molecular Biology of the Cell, 2013
Pattarawut Sopha
exaly  

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

Proceedings of the National Academy of Sciences of the United States of America, 2011
P D J Grootenhuis, Kimberly S Straley, Jeffrey J Wine   +2 more
exaly  

Resolving the blazar CGRaBS J0809+5341 in the presence of telescope systematics

Monthly Notices of the Royal Astronomical Society, 2017
Iniyan Natarajan, Zsolt Paragi, Jonathan T L Zwart   +2 more
exaly  

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells

PLoS ONE, 2015
Bruce A Stanton
exaly  

Synergy-Based Small-Molecule Screen Using a Human Lung Epithelial Cell Line Yields ΔF508-CFTR Correctors That Augment VX-809 Maximal Efficacy

Molecular Pharmacology, 2014
Puay-Wah Phuan, Guido Veit, Ariel Roldan
exaly  

Evaluation of 1,2,3‐Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX‐770 and VX‐809

Chemistry - A European Journal, 2019
Gary W Breton, Steven M Rowe, Msph, Stephen G Aller   +2 more
exaly  

Combined effects of VX-770 and VX-809 on several functional abnormalities of F508del-CFTR channels

Journal of Cystic Fibrosis, 2014
exaly  

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

Proceedings of the National Academy of Sciences of the United States of America, 1990
exaly