Results 131 to 140 of about 95,719 (293)

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Lithium Niobate Electro‐Optic Photonic Processor for Variational Quantum Eigensolver

Advanced Science, EarlyView.
An integrated lithium‐niobate‐on‐insulator ququart processor implements an electro‐optically controlled photonic variational quantum eigensolver using single photons encoded in four path modes. Bell‐basis‐emulating ququart projective measurements reduce measurement settings while achieving chemical‐accuracy‐level molecular‐energy estimation.
Jinil Lee, Ui Joon Park, Minho Choi, Hyeong‐Soon Jang, Sunghyun Moon, Hyeon Hwang, Min‐Kyo Seo, Dae‐Hwan Ahn, Sang‐Wook Han, Yong‐Su Kim, Hyounghan Kwon, Hojoong Jung   +11 more
wiley   +1 more source

Soft Hypoxia‐Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed‐Loop Therapeutics of Chronic Wounds

Advanced Science, EarlyView.
Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu, Bowen Yang, Cao Qi, Zhijie Zhou, Haochen Zou, Anjum Qureshi, Xiao Zhao, Ting Li, Li Gao, Ye Tao, Gang Song, Pingqiang Cai, Zheng Li, Zhiyuan Liu, Dianpeng Qi, Ting Wang, Lianhui Wang   +16 more
wiley   +1 more source

Ligand Engineering Enables Bifacial PbS All-QD Homojunction Photodiodes [PDF]

Infrared PbS quantum dot (QD) photodiodes play a vital role in various applications, including photovoltaics, light-emitting diodes, lasers, and photodetectors.
Mei, Tingting, Guan, X, Li, M, Chu, D, Su, D, Guan, Xinwei, Chen, Chao, Peng, S, Su, Dawei, Chen, C, Xu, H, Xu, Haolan, Chu, Dewei, Wu, T, https://orcid.org/, Chen, F, Li, Mengyao, Wu, Tom, Wan, T, Lin, CH, Huang, S, Dong, B, Li, Xiaoning, Hu, L, Li, Zhi, Gao, Liang, Mei, T, Chen, Fandi, Gao, L, Peng, Shuhua, Li, Z, Hu, Long, Han, Zhaojun, Han, Z, Li, X, Wan, Tao, Lin, Chun Ho, Huang, Shujuan, Dong, Beining   +38 more
core   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Grain Boundary Structure Ordering via Electroshock Treatment Enhances Strength‐Ductility Synergy

Advanced Science, EarlyView.
Electroshock treatment triggers atomic rearrangement, transforming disordered grain boundaries into ordered states without inducing recrystallization. This grain boundary ordering effectively relieves strain concentration and strengthens boundaries, enabling a simultaneous improvement in both strength and ductility.
Jiancheng Chen, Feng Wang, Dongsheng Qian, Huiling Wang, Jinsong Wu, Mingwang Fu, Lin Hua   +6 more
wiley   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Liposome-QD Hybrids & the Development of Targeted Theranostic Modalities [PDF]

, 2010
The construction of theranostic nanoscale constructs integrating imaging and therapy into one unit has attracted enormous interest for various biomedical applications.
Tian, Bowen
core  

Light‐Absorbing‐Layer‐Free Flash Lamp Annealing for High‐Throughput Fabrication of All‐Solution‐Processed Oxide Electronics

Advanced Science, EarlyView.
A flash lamp annealing strategy using a mullite chuck enables rapid conversion of sol–gels to metal oxides on silicon and ultra‐thin glass without extra light‐absorbing layers. Direct light absorption initiates the transformation, and the low thermal conductivity of mullite promotes heat accumulation.
Zetong Li, Wei He, Guangji Wang, Jingwei Zhang, Zhimin Chai, Xinchun Lu   +5 more
wiley   +1 more source