Results 51 to 60 of about 93,483 (103)

Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway

open access: yesMolecules, 2019
Bilobalide, the only sesquiterpene compound from Ginkgo biloba leaf, exhibits various beneficial pharmaceutical activities, such as antioxidant, anti-inflammation, and protective effects for the central nervous system.
Su Bu   +4 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

open access: yesMolecules, 2019
Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed.
Halil I. Ciftci   +13 more
doaj   +1 more source

Inhibition of Cancer Derived Cell Lines Proliferation by Synthesized Hydroxylated Stilbenes and New Ferrocenyl-Stilbene Analogs. Comparison with Resveratrol

open access: yesMolecules, 2014
Further advances in understanding the mechanism of action of resveratrol and its application require new analogs to identify the structural determinants for the cell proliferation inhibition potency.
Malik Chalal   +4 more
doaj   +1 more source

Long-term monitoring of PKS 0537−441 with Fermi–LAT and multiwavelength observations [PDF]

open access: yes, 2013
We report on multiwavelength observations of the blazar PKS 0537-441 (z = 0.896) obtained from microwaves through gamma-rays by Submillimeter Array, Rapid Eye Mounting, Automatic Telescope for Opti ...
F. D’Ammando   +30 more
semanticscholar   +1 more source

TEM Nano-Moiré Pattern Analysis of a Copper/Single Walled Carbon Nanotube Nanocomposite Synthesized by Laser Surface Implanting

open access: yesC, 2018
In our previous studies, we have developed a wet process to synthesize a copper-single walled carbon nanotube (Cu–SWCNT) metal nanocomposite with excellent mechanical properties. The nanostructure of this Cu–SWCNT composite was confirmed independently by
Jay F. Tu
doaj   +1 more source

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203

open access: yesMolecules, 2017
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa   +6 more
doaj   +1 more source

Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

open access: yesMolecules, 2016
A series of new conjugated compounds with a –SCH2– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them ...
Shwu-Chen Tsay   +11 more
doaj   +1 more source

Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.

open access: yesChest, 2013
BACKGROUND Long-term survival after lung transplant is limited by the development of chronic and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome (BOS). While prior studies strongly implicate cellular rejection as a
Laurie D. Snyder   +7 more
semanticscholar   +1 more source

Retro-Curcuminoids as Mimics of Dehydrozingerone and Curcumin: Synthesis, NMR, X-ray, and Cytotoxic Activity

open access: yesMolecules, 2016
Curcumin and its derivatives have been extensively studied for their remarkable medicinal properties, and their chemical synthesis has been an important step in the optimization of well-controlled laboratory production.
Marco A. Obregón-Mendoza   +9 more
doaj   +1 more source

Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell Models of Vascular Inflammation: Protective Role in Degenerative and Inflammatory Diseases

open access: yesMolecules, 2016
Matrix metalloproteinases (MMPs) are endopeptidases responsible for the hydrolysis of various components of extracellular matrix. MMPs, namely gelatinases MMP-2 and MMP-9, contribute to the progression of chronic and degenerative diseases.
Nadia Calabriso   +6 more
doaj   +1 more source

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