Results 101 to 110 of about 14,659 (232)

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, EarlyView.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Stabilization Strategies for Carbon Based Perovskite Solar Cells Under Light, Heat, and Humidity

EcoEnergy, EarlyView.
Carbon‐based MA1−x(AVA)xPbI3/CsPbBr3 QD heterostructures fabricated under ambient conditions exhibit < 5% loss under ISOS‐D‐3 and reversible photo‐induced degradation, revealing the dual role of QDs in defect passivation and dynamic interfacial stabilization.
Emilie Planes, Fatou Diaw‐Ndiaye, Lara Perrin, Maria Bernechea, Lionel Flandin   +4 more
wiley   +1 more source

Synergistic Optical Strategies for Enhanced Perovskite Photocatalytic Activity

EcoEnergy, EarlyView.
This review addresses bottlenecks of halide perovskites' photoactive components from an optics‐driven perspective and organizes recent advances into four interconnected design principles. This review provides practical design principles and outlines key directions toward efficient, selective, and stable perovskite photocatalysis for CO2 reduction ...
Jaemin Jeong, Myeongjin Seol, Sang Hyun Ahn, Soo Young Kim   +3 more
wiley   +1 more source

Molecular‐Level Modulation of Proton Transport via Electron‐Proton Coupling in Bio‐p‐n Junctions

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
We developed a pH‐sensing device capable of operating in biological environments. A biohybrid p–n junction was constructed using bacteriorhodopsin (bR) and the photoconductive polymer poly(3‐hexylthiophene) (P3HT). Under light illumination, the photocurrent exhibits distinct transitions across various pH gradients, demonstrating the system's high ...
Chen Song, Yujia Lv, Haotian Pang, Haoqi Fan, Jiayin Huang, Weibin Zhou, Dan Luo, Aochen Wang   +7 more
wiley   +1 more source

Dual‐Mode Electrophoretic Displays Enabled by Quantum Dot‐Decorated PR48:2 Pigment Particles and TiO2 for All‐Weather Visibility, Excellent Bistability, and Enhanced Readability

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study presents a novel quantum dot electrophoretic display (QDEPD), which combines electro‐controlled reflection and optically‐triggered emission to achieve efficient multi‐modal switching within a single pixel. By incorporating multi‐component nanostructures, the system enhances functional integration and multi‐modal response capabilities.
Xingke Zheng, Yun Ye, Hongxing Xie, Yuanyi Liu, Ruihan Lin, Guangyou Liu, Tianyong Guan, Enguo Chen, Tailiang Guo   +8 more
wiley   +1 more source

Dual Operating Mode Imaging Photodetector Based on Electrical Modulation of p‐Si/MgO/ZnO

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This research innovatively introduces the MgO barrier layer and utilizes the device structure advantages of MSM to achieve breakthrough dual‐band response output of p‐Si/MgO/ZnO photodetectors under bias modulation. It has been successfully applied in dual‐mode imaging, laying the foundation for the development of third‐generation imaging technology ...
Hepeng Zhao, Qiyin Wang, Man Zhao, Dayong Jiang, Qingcheng Liang   +4 more
wiley   +1 more source

Next-generation quantum dot solar cells: advances in materials, device engineering and performance optimization. [PDF]

RSC Adv
Habiba U, Khan MU, Sultan N, Saeed Ashraf Janjua MR.   +3 more
europepmc   +1 more source