Results 1 to 10 of about 536,981 (86)

Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts.

open access: yesPLoS Computational Biology, 2022
Nucleosomes are recognized as key regulators of transcription. However, the relationship between slow nucleosome unwrapping dynamics and bulk transcriptional properties has not been thoroughly explored. Here, an agent-based model that we call the dynamic
Robert C Mines   +2 more
doaj   +1 more source

Combination and competition between path integration and landmark navigation in the estimation of heading direction.

open access: yesPLoS Computational Biology, 2022
Successful navigation requires the ability to compute one's location and heading from incoming multisensory information. Previous work has shown that this multisensory input comes in two forms: body-based idiothetic cues, from one's own rotations and ...
Sevan K Harootonian   +2 more
doaj   +1 more source

STENCIL: A web templating engine for visualizing and sharing life science datasets.

open access: yesPLoS Computational Biology, 2022
The ability to aggregate experimental data analysis and results into a concise and interpretable format is a key step in evaluating the success of an experiment.
Qi Sun   +5 more
doaj   +1 more source

Elucidating multi-input processing 3-node gene regulatory network topologies capable of generating striped gene expression patterns.

open access: yesPLoS Computational Biology, 2022
A central problem in developmental and synthetic biology is understanding the mechanisms by which cells in a tissue or a Petri dish process external cues and transform such information into a coherent response, e.g., a terminal differentiation state.
Juan Camilo Arboleda-Rivera   +3 more
doaj   +1 more source

Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling.

open access: yesPLoS Computational Biology, 2022
Supervised machine learning applications in health care are often limited due to a scarcity of labeled training data. To mitigate the effect of small sample size, we introduce a pre-training approach, Patient Contrastive Learning of Representations (PCLR)
Nathaniel Diamant   +5 more
doaj   +1 more source

gmxapi: A GROMACS-native Python interface for molecular dynamics with ensemble and plugin support.

open access: yesPLoS Computational Biology, 2022
Gmxapi provides an integrated, native Python API for both standard and advanced molecular dynamics simulations in GROMACS. The Python interface permits multiple levels of integration with the core GROMACS libraries, and legacy support is provided via an ...
M Eric Irrgang   +2 more
doaj   +1 more source

Meta-control of social learning strategies.

open access: yesPLoS Computational Biology, 2022
Social learning, copying other's behavior without actual experience, offers a cost-effective means of knowledge acquisition. However, it raises the fundamental question of which individuals have reliable information: successful individuals versus the ...
Anil Yaman   +4 more
doaj   +1 more source

Chthonius (Globochthonius) daorsoni n.sp. (Chthoniidae, Pseudoscorpiones): A new cave false scorpion from Bosnia and Herzegovina [PDF]

open access: yesArchives of Biological Sciences, 2014
A new endemic pseudoscorpion species from the Jama Pit nr. Daorson, Stolac, Southeastern Bosnia and Herzegovina, is presented, thoroughly described and illustrated. It is named Chthonius (Globochthonius) daorsoni n. sp.
Ćurčić B.P.M.   +6 more
doaj   +1 more source

Pyroptosis-Related Gene Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Glioma

open access: yesFrontiers in Cell and Developmental Biology, 2022
Objective: Gliomas are the most common primary tumors in the central nervous system with a bad prognosis. Pyroptosis, an inflammatory form of regulated cell death, plays a vital role in the progression and occurrence of tumors.
Yulian Zhang   +13 more
doaj   +1 more source

Hdh-Tektin-4 Regulates Motility of Fresh and Cryopreserved Sperm in Pacific Abalone, Haliotis discus hannai

open access: yesFrontiers in Cell and Developmental Biology, 2022
As structural components of sperm, tektins are thought to play a fundamental role in sperm flagellar motility. In this study, Tektin-4 (Hdh-TEKT4) gene was successfully cloned and characterized from the testis tissue in Pacific abalone, Haliotis discus ...
Zahid Parvez Sukhan   +4 more
doaj   +1 more source

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