Results 41 to 50 of about 56,475 (99)

TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling

Cell Death and Disease, 2021
T-complex protein 1 (TCP1) is one of the subunits of chaperonin-containing T complex (CCT), which is involved in protein folding, cell proliferation, apoptosis, cell cycle regulation, and drug resistance.
Xiaofang Chen, Xianling Chen, Yiping Huang, Jia Lin, Yong Wu, Yuanzhong Chen   +5 more
doaj   +1 more source

Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Carry MicroRNA-671 to Alleviate Myocardial Infarction Through Inactivating the TGFBR2/Smad2 Axis

Inflammation, 2021
Mesenchymal stem cells (MSCs) and their derived extracellular vesicles have been reported as promising tools for the management of heart disease. The aim of this study was to explore the function of adipose-derived MSCs (adMSCs)-derived exosomes (Exo) in
Xue Wang, Yuhai Zhu, C. Wu, Wennan Liu, Yujie He, Qing Yang   +5 more
semanticscholar   +1 more source

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

Cell Death and Disease, 2021
Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells.
Nunzio Vicario, Federica M. Spitale, Daniele Tibullo, Cesarina Giallongo, Angela M. Amorini, Grazia Scandura, Graziana Spoto, Miriam W. Saab, Simona D’Aprile, Cristiana Alberghina, Renata Mangione, Joshua D. Bernstock, Cirino Botta, Massimo Gulisano, Emanuele Buratti, Giampiero Leanza, Robert Zorec, Michele Vecchio, Michelino Di Rosa, Giovanni Li Volti, Giuseppe Lazzarino, Rosalba Parenti, Rosario Gulino   +22 more
doaj   +1 more source

CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/β-catenin signaling due to modulating miR-671-5p/FZD4 axis

BMC Pulmonary Medicine, 2022
Introduction Accumulating evidence highlights the critical roles of circular RNAs (circRNAs) in the malignant progression of cancers. In this study, we investigated the expression pattern of a newly identified circRNA (hsa_circ_0017109) in non–small cell
Bo Yang, Bin Zhang, Qi Qi, Changli Wang
semanticscholar   +1 more source

VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway

Cell Death and Disease, 2021
Clear cell renal cell carcinomas (ccRCC) reprogram carbon metabolism responses to hypoxia, thereby promoting utilization of glutamine. Recently, sirtuin 4 (SIRT4), a novel molecular has turned out to be related to alternating glutamine metabolism and ...
Ying Tong, Jinyan Kai, Shuo Wang, Yiwen Yu, Suhong Xie, Hui Zheng, Yanchun Wang, Yixuan Liu, Keyu Zhu, Xiaolin Guan, Lin Guo, Renquan Lu   +11 more
doaj   +1 more source

B7–H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction

Cell Death and Disease, 2021
While their function, as immune checkpoint molecules, is well known, B7-family proteins also function as regulatory molecules in bone remodeling. B7–H3 is a receptor ligand of the B7 family that functions primarily as a negative immune checkpoint.
Younseo Oh, Robin Park, So Yeon Kim, Sung-ho Park, Sungsin Jo, Tae-Hwan Kim, Jong Dae Ji   +6 more
doaj   +1 more source

c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA

Cell Death and Disease, 2021
The c-Myc oncoprotein plays a prominent role in cancer initiation, progression, and maintenance. Long noncoding RNAs (lncRNAs) are recently emerging as critical regulators of the c-Myc signaling pathway.
Bingyan Li, Guang Zhang, Zhongyu Wang, Yang Yang, Chenfeng Wang, Debao Fang, Kaiyue Liu, Fang Wang, Yide Mei   +8 more
doaj   +1 more source

CircRNA circ_0092314 Induces Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells via Elevating the Expression of S100P by Sponging miR-671

Frontiers in Oncology, 2021
Background Circular RNAs (circRNAs) is a novel class of non-coding RNAs that regulate gene expression during cancer progression. Circ_0092314 is a newly discovered circRNA that was upregulated in pancreatic cancer (PAAD) tissues.
Q. Shen, G. Zheng, Yi Zhou, Jin Tong, Sanpeng Xu, Hui Gao, Xiaofan Zhang, Q. Fu   +7 more
semanticscholar   +1 more source

LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer

Cell Death and Disease, 2021
LncRNAs play essential regulatory roles in pancreatic cancer (PC) tumorigenesis and progression. We aimed to investigate the role of lncRNA CERS6-AS1 in PC. CERS6-AS1 expression was determined in PC tissues and cell lines by PCR analysis.
Jian Xu, Jie Wang, Zhiwei He, Peng Chen, Xueyi Jiang, Yankun Chen, Xinyuan Liu, Jianxin Jiang   +7 more
doaj   +1 more source

circ-PTTG1IP/miR-671-5p/TLR4 axis regulates proliferation, migration, invasion and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis.

General Physiology and Biophysics, 2021
Circular RNAs (circRNAs) are related to rheumatoid arthritis (RA) development. However, the function and mechanism of circRNA pituitary tumor-transforming 1 interacting protein (circ- PTTG1IP) in RA are unknown. The expression of circ-PTTG1IP in synovial
Lifeng Chen, Hesong Huang, Li Chen, Li Xu, Jianhua Chen, Q. Lu   +5 more
semanticscholar   +1 more source