Results 71 to 80 of about 462 (153)

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Large‐Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

Journal of Clinical Laboratory Analysis, EarlyView.
Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou, Shandra Jones, Juan Montes, Jonathan Ritter, Li‐Yu Shih, Chia‐Jung Chan, Ying‐Chou Lin, Min Chen, Shih‐Yin Chen, Ning Wu   +9 more
wiley   +1 more source

An Efficient Elastic Net with Regression Coefficients Method for Variable Selection of Spectrum Data. [PDF]

PLoS One, 2017
Liu W, Li Q.
europepmc   +1 more source

Spreading quality improvement in bronchiolitis care: A qualitative study of barriers and facilitators to de‐implementation efforts across Alberta′s healthcare settings

Journal of Hospital Medicine, EarlyView.
Abstract Background Low‐value care remains prevalent in bronchiolitis management despite evidence‐based guidelines. De‐implementation initiatives face unique challenges compared with traditional implementation efforts, particularly when spreading across diverse healthcare settings.
Nathan M. Solbak, Ashleigh Jensen, Erin Thompson, Aaron Peterson, Lily Ragan, Daina Thomas, David W. Johnson, J. A. Michelle Bailey   +7 more
wiley   +1 more source

Optical Kerr Gating as a Strategy for Noise Reduction in Femtosecond Stimulated Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
We report an experimental approach, where an Optical Kerr gate is incorporated with Femtosecond Stimulated Raman Spectrometry (FSRS). The gate functions as a temporal filter that preferentially suppresses the FSRS inherent background. FSRS spectra are reported with the Kerr‐gated methodology with significantly improved SNR compared to the conventional ...
Spyridon Kaziannis, Lazaros Varvarezos, Sotiris Danakas, Elissavet Karkadaki, Cesar Bernando, Miroslav Kloz   +5 more
wiley   +1 more source

Coupling Water Purification and Carbon Sequestration at Various Spatial Scales From Supply and Demand Perspective

Land Degradation &Development, EarlyView.
ABSTRACT Balancing ecosystem‐service supply and demand is central to understanding both the natural and social dimensions of ecosystem services and to enhancing human well‐beings. Concurrently, collaborative efforts are underway to improve multiple ecosystem services, including the promotion of carbon neutrality and water purification (WP) within basin
Jing Cheng, Mingyang Ding, Zhenya Zhu, Xinping Luo, Xin Huang, Chunbo Huang   +5 more
wiley   +1 more source

Identification of relevant subtypes via preweighted sparse clustering. [PDF]

Comput Stat Data Anal, 2017
Gaynor S, Bair E.
europepmc   +1 more source

A DUF3455 domain‐containing protein promotes Ustilaginoidea virens infection and functions as a plant immune elicitor

New Plant Protection, EarlyView.
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang, Wen Zhang, Wenyue Zheng, Qian Zhang, Mina Yu, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yunpeng Wang, Yongfeng Liu, Tianqiao Song   +13 more
wiley   +1 more source