Results 51 to 60 of about 605,753 (293)

A Novel Electrochemical Sensor Based on SH-β-cyclodextrin Functionalized Gold Nanoparticles/Reduced-Graphene Oxide Nanohybrids for Ultrasensitive Electrochemical Sensing of Acetaminophen and Ofloxacin

International Journal of Electrochemical Science, 2017
A novel electrochemical sensor based on SH-β-cyclodextrin functionalized gold nanoparticles/reduced-graphene oxide (SH-β-CD/AuNPs/rGO) nanohybrids for ultrasensitive electrochemical sensing of acetaminophen and ofloxacin was developed.
Zhiming Jiang, Guangyu Li, Mingxiao Zhang   +2 more
doaj   +1 more source

Assessing the Short-Term Efficacy and Safety of Guselkumab for Moderate-to-Severe Plaque Psoriasis: Meta-Analysis of Randomized Controlled Trials

Journal of Immunology Research, 2020
Background. To investigate the efficacy and safety of guselkumab in the treatment of moderate-to-severe plaque psoriasis. Methods. A systematic review was undertaken to identify double-blind randomized controlled trials (RCTs).
Jing Yang, Zongming Wang, Xilin Zhang
doaj   +1 more source

Changing perceptions of the Qing Dynasty in the Late Joseon Dynasty and Chinese style architecture that emerged in Joseon in the 18th century

Journal of Asian Architecture and Building Engineering, 2022
This study examines changing perceptions of China’s Qing Dynasty within the Joseon Dynasty, focusing on Chinese-style buildings during the late Joseon period (18th-19th).
Myengsoo Seo
doaj   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity

Journal of Diabetes Research, 2016
Apoptosis of islet β cells is a primary pathogenic feature of type 2 diabetes, and ER stress and mitochondrial dysfunction play important roles in this process.
Wu QiNan, Gan XiaGuang, Lei XiaoTian, Deng WuQuan, Zhang Ling, Chen Bing   +5 more
doaj   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

Advanced Science, EarlyView.
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao, Yue Peng, Qing Liang, Shi Liu, Yang Li, Lei Ma, Menghan Hu, Sujuan Zheng, Zhihua Liu, Shugeng Gao   +9 more
wiley   +1 more source

Towards the sustainable financial management in green economic growth through big data technology innovation; Case study in China

Heliyon
This study addresses the critical challenge of integrating sustainable financial management within the framework of green economic growth in China from 1990 to 2022, underscored by rapid industrialization and environmental concerns. The primary aim is to
Zhu Lina
doaj   +1 more source