Results 61 to 70 of about 149,199 (212)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Strain‐Preserving Transfer of Freestanding Oxide Membranes for Tunable Magnetic Anisotropy

Advanced Science, EarlyView.
An epoxy‐assisted exfoliation and transfer strategy circumvents the trade‐off between structural flexibility and strain tunability in freestanding oxide membranes. Epitaxial strain is effectively preserved, enabling versatile and robust control of magnetic anisotropy without sacrificing flexibility.
Jinfeng Zhang, Yuyue Zhao, Shouzhe Dong, Jingdi Lu, Qing Wang, Fang Xu, Ao Wang, Kunjie Dai, Yueming Huang, Zhengguo Liang, Qiming Lv, Houbing Huang, Wenbin Wu, Lingfei Wang   +13 more
wiley   +1 more source

The clinical potential of 1,5-anhydroglucitol as biomarker in diabetes mellitus

Frontiers in Endocrinology
A crucial measure of diabetes management is to monitor blood glucose, which often requires continuous blood collection, leading to economic burden and discomfort.
Haiying Xu, Renyin Chen, Xiaoli Hou, Na Li, Yanwei Han, Shaoping Ji, Shaoping Ji   +6 more
doaj   +1 more source

Comparison of patient outcomes with and without stenting tube in pancreaticoduodenectomy

Journal of International Medical Research, 2018
Objective To evaluate the clinical effect of different pancreaticojejunostomy techniques in the treatment of pancreaticoduodenectomy and investigate the applicability of pancreaticojejunostomy without pancreatic duct stenting.
Xiong Bin, Bai Lian, Gong Jianping, Tu Bin   +3 more
doaj   +1 more source

Photoelectric‐Coupled Ferroelectric Heterojunctions for Ultrahigh NO2 Sensing With Polarization‐Memory‐Assisted Interfacial Modulation

Advanced Science, EarlyView.
This study demonstrates a Bi2WO6/SrBi2Ta2O9 heterojunction where light‐driven ferroelectric polarization reversal couples with persistent photoconductivity, enabling exclusive NO2 selective room‐temperature sensing. The device achieves a two‐order‐of‐magnitude sensitivity enhancement over an unpolarized device, a sub‐ppb detection limit, and robust ...
Liping Tan, Xuefeng Hu, Ming Zhou, Weiwei Qing, Along Li, Zilong Wang, Mudan Feng, Shuang Zhao, Xiaoliang Wang, Peipei Li, Yali Bi, Wei Zhang   +11 more
wiley   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

1878-1881 Yilliridiki “İli Krizisi” ve Uniñ Aqiviti [PDF]

Uluslararası Uygur Araştırmaları Dergisi, 2014
Yakup Bey’in Tanrı Dağları’nın güney bölgesini kontrol altına alarak Yetteşeher Devleti’ni kurduğu 1865 yılında Tanrı Dağları’nın kuzeyindeki İli bölgesinde “İli/Tarançı Sultanlığı” kurulmuştu.
Nebijan TURSUN
doaj   +2 more sources

The “Hand as Foot” teaching method in cleansing and disinfection of the ophthalmic power system

Asian Journal of Surgery, 2023
Jin Xia Qin, Yao Chen, Jin Xiang Chen, Fang Zeng   +3 more
doaj   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Flame‐Retardant Quasi‐Solid‐State Electrolytes From Self‐Assembled Azolate Hybrid Frameworks for Highly Safe Lithium Batteries

Angewandte Chemie, EarlyView.
This work develops a spray‐assisted in situ assembly technique to construct AHF materials with nitrogen/oxygen‐regulated one‐dimensional channels on glass fiber, providing abundant active sites and enabling rapid transport for lithium ions. Subsequently, phosphate flame retardants are encapsulated via in situ polymerization, resulting in a thermally ...
Shun Wang, Qimin Zhu, Yuanyuan Tian, Peiyu Cui, Qing Ji, Tian Xie, Hong Wang, Dong Zhou, Guoxiu Wang, Wenhuan Huang   +9 more
wiley   +2 more sources