Results 61 to 70 of about 605,753 (293)

Book review: China’s political economy in modern times: changes and economic consequences, 1800-2000 [PDF]

, 2013
"China’s Political Economy in Modern Times: Changes and Economic Consequences, 1800-2000." Kent Deng. Routledge. October 2012. --- This book aims to make an important contribution to the study of changes in China’s institutions and their impact on the ...
Yun, Yan
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Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

The real-world safety of Nivolumab: a pharmacovigilance analysis based on the FDA adverse event reporting system

Frontiers in Immunology
BackgroundNivolumab, a human immunoglobulin IgG4 monoclonal antibody targeting PD-1 receptor, received initial FDA approval in 2014 for treating unresectable or metastatic malignant melanoma (MM), followed by approval for metastatic squamous and non ...
Yutong Wu, Yue Zhou, Shiyue Xia, Zhaoyou Meng   +3 more
doaj   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

State-Of-Charge Estimation for Lithium-Ion Battery Using Improved DUKF Based on State-Parameter Separation

Energies, 2019
State-of-charge estimation and on-line model modification of lithium-ion batteries are more urgently required because of the great impact of the model accuracy on the algorithm performance.
Chuan-Xiang Yu, Yan-Min Xie, Zhao-Yu Sang, Shi-Ya Yang, Rui Huang   +4 more
doaj   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

Population pharmacokinetics of polymyxin B in critically ill patients with carbapenem-resistant organisms infections: insights from steady-state trough and peak plasma concentration

Frontiers in Pharmacology
AimsTo establish a population pharmacokinetic (PopPK) model of polymyxin B (PMB) in critically ill patients based on steady-state trough (Ctrough,ss) and peak (Cpeak,ss) concentrations, optimize the dosing regimen, and evaluate the consistency of 24-hour
Jun Yang, Mingjie Yu, Yu Gan, Lin Cheng, Ge Yang, Lirong Xiong, Fang Liu, Yongchuan Chen   +7 more
doaj   +1 more source

Photonuclear Population of 229m,gTh in Th‐Doped Crystals Toward Nuclear Clock Development

Advanced Science, EarlyView.
This study demonstrates a novel photonuclear approach for producing the nuclear clock isomer 229mTh in thorium‐doped crystals, overcoming current supply limitations. Through cross‐section calculations and Monte Carlo simulations, we identify optimal crystal materials and irradiation conditions, achieving high signal‐to‐noise ratios.
Hao‐Yang Lan, Di Wu, Mei‐Zhi Wang, Zhong‐Yi Chen, Jian‐Feng Lv, Yu‐Hui Xia, Zhe‐Nan Wang, Wen Luo, Xin‐Lu Xu, Xue‐Qing Yan   +9 more
wiley   +1 more source

Investigation and analysis of influencing factors on the economic burden of varicella disease in Qingyang, China, 2024

Human Vaccines & Immunotherapeutics
This study aims to evaluate the economic burden and associated determinants of varicella cases in Qingyang City, Gansu Province, thereby informing the formulation and effectiveness evaluation of varicella prevention and control strategies.
Beiqin Liu, Xueping Li, Huailu Shi, Lin Yuan, Yongfeng Jing, Yuelong Hui, Meimei Xu, Yan Zhang, Kangjun Zhao, Qiqi Sun, Jingyu Fan, Mingyu Yang   +11 more
doaj   +1 more source

Method and Meaning: Selections from the Gettysburg College Collection

, 2014
What is art historical study and how it should be carried out are fundamental questions the exhibition Method and Meaning: Selections from the Gettysburg College Collection intends to answer.
Callahan, Shannon, Cantele, Ashlie M., D\u27Amico, Maura E., Duan, Xiyang, Garnick, Devin N., Gross, Allison J., Sun, Yan, Zbehlik, Emily A.   +7 more
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