Results 181 to 190 of about 3,934 (296)

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

Stakeholder consensus of quality indicators for end-of-life cancer care in Malaysia: a modified Delphi study. [PDF]

BMC Palliat Care
Wong WJ, Hwong WY, Teoh CCO, McCarthy SA, Subramaniam Kalianan R, Ng CJ.   +5 more
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Quality indicators for palliative care for older people: An umbrella review. [PDF]

Palliat Med
Hutchison A, Spooner A, Parker D, Yates P.   +3 more
europepmc   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Long-Term Impact of EGUIDE Training on Facility-Wide Guideline Adherence Rate in Schizophrenia and Major Depressive Disorder: A Multicenter Study. [PDF]

Neuropsychopharmacol Rep
Hasegawa N, Muraoka H, Arai Y, Horinouchi T, Yamamuro K, Hashimoto N, Ochi S, Tsuboi T, Kawamata Y, Nakamura T, Yasuda Y, Matsumoto J, Ito S, Onitsuka T, Ohi K, Numata S, Hori H, Inada K, Watanabe K, Yasui-Furukori N, Hashimoto R.   +20 more
europepmc   +1 more source

Faster and Durable: A Cell‐to‐System Validation of a Low‐Degradation Fast‐Charge Protocol for Li‐Ion Batteries

Advanced Science, EarlyView.
A physics‐based framework resolving graphite phase‐separation dynamics establishes a predictive, degradation‐aware fast‐charging methodology for commercial Li‐ion batteries. The resulting model‐informed protocol achieves 20%–80% state‐of‐charge in 14 min while matching the long‐term degradation of a commercial 25‐minute EV strategy.
Marco Lagnoni, Francesco Giuseppe Quilici, Davide Cademartori, Claudio Scarpelli, Uways Nurulain Mithoowani, Federica Barontini, Alessandro Ruvio, Monica Puccini, Giovanni Lutzemberger, Maria Paola Carpanese, Antonio Bertei   +10 more
wiley   +1 more source

Palliative care and end-of-life quality indicators in critical patients in ICU: systematic review protocol. [PDF]

BMJ Open
Suwardianto H, Effendy C, Setiyarini S.
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Comprehensive Per- and Polyfluorinated Substances Profiling in Beverages: Simultaneous Quantification of Ultrashort-Chain to Long-Chain Compounds in Ready-to-Drink Teas and Fruit Juices. [PDF]

Toxics
Liang SH, Steimling JA.
europepmc   +1 more source