Results 181 to 190 of about 31,388 (284)

Improvement of Cancer Care-Analysis of ESGO Quality Indicators for the Surgical Treatment of Endometrial Cancer in Slovenian and Croatian Gynaecologic Oncology Departments. [PDF]

Medicina (Kaunas)
Pakiž M, Klarić M, Dovnik A, Primorac GS, Knez J, Despot Đ, Al Mahdawi L, Pranjic M, Brumec A, Turković T, Cokan A.   +10 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Quality indicators for safe and effective use of medications in long-term care settings: A systematic review. [PDF]

Br J Clin Pharmacol
Gutteridge DS, Calder AH, Stasinopoulos J, Javanparast S, Caughey GE, Hillen JB, Stafford AC, Peterson GM, Inacio MC, Khadka J, Kalisch Ellett LM, Jackson SL, Hibbert PD, Cations ML, Corlis ME, Yu SC, Clark MJ, Soulsby NR, Manias E, Yoo GH, Sluggett JK.   +20 more
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Assessment of ESGO Quality Indicators and Factors Associated with Recurrence Following Surgery for Early-Stage Cervical Cancer: A Retrospective Cohort Study. [PDF]

J Clin Med
Espías-Alonso M, Gorostidi M, Zapardiel I, Gracia M.   +3 more
europepmc   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Multidisciplinary Clinical Quality Indicators for Head and Neck Cancer: A Modified Delphi Study in Australia. [PDF]

ANZ J Surg
Venchiarutti RL, Sharman AR, Donnelly C, Andrews N, Batstone M, Bhuta S, Gupta R, Jeans C, Lee J, Ooi EH, Schifter M, Sundaresan P, Tan ST, Whelan D, Eva Yabe T, Zhou M, Palme CE, Clark JR.   +17 more
europepmc   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

From Knowledge Graphs to Digital Twins: Perspectives on Modeling Patient Outcomes for Health Care Quality Assessment.

J Med Internet Res
Nitschke AK, Diaz Ochoa JG, Neumaier S, Knott M.   +3 more
europepmc   +1 more source