Results 51 to 60 of about 93,796 (121)

The effects of myosteatosis on skeletal muscle function in older adults

Physiological Reports
Myosteatosis, or the infiltration of fatty deposits into skeletal muscle, occurs with advancing age and contributes to the health and functional decline of older adults.
Kathleen Dondero, Ben Friedman, Julie Rekant, Rian Landers‐Ramos, Odessa Addison   +4 more
doaj   +1 more source

Sedentary Behaviour in Human Health and Disease

, 2018
Sedentary behaviour – too much sitting as distinct from too little physical activity – is now recognised as an independent risk factor for several health outcomes and premature mortality.
Daniel P. Bailey
core   +1 more source

SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacitidine in preclinical models of acute myeloid leukemia

, 2023
Acute myeloid leukemias (AML) are severe hematomalignancies with dismal prognosis. The post-translational modification SUMOylation plays key roles in leukemogenesis and AML response to therapies. Here, we show that TAK-981 (subasumstat), a first-in-class
Rawan Hallal, de Toledo, Marion, Abigaïl Delort, Mays Aqrouq, Marion De Toledo, Guillaume Bossis, Clara Recasens-Zorzo, Tempé, Denis, Cartron, Guillaume, Hallal, Rawan, Chakraborty, Mehuli, Recasens-Zorzo, Clara, Marc Piechaczyk, Mehuli Chakraborty, Bossis, Guillaume, Aqrouq, Mays, Buonocore, Giovanni, Delort, Abigaïl, Giovanni Buonocore, Piechaczyk, Marc, Akl, Dana, Ludovic Gabellier, Gabellier, Ludovic, Dana Akl, Guillaume Cartron, Denis Tempé   +25 more
core   +1 more source

Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study

Physiological Reports
The pathophysiology behind sodium retention in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. We hypothesized that patients with HFpEF have impaired natriuresis and diuresis in response to volume expansion and diuretic ...
Adhish Agarwal, Srinivasan Beddhu, Robert Boucher, Veena Rao, Nirupama Ramkumar, Aylin R. Rodan, Jacob Fang, Brandi M. Wynne, Stavros G. Drakos, Thomas Hanff, Alfred K. Cheung, James C. Fang   +11 more
doaj   +1 more source

The Adrenergic System in Cardiovascular Physiology and Pathophysiology, 2nd Edition

, 2015
Cardiovascular diseases pose an enormous clinical challenge, remaining the most common cause of death in the world. ß-adrenoceptors play an important role on cardiac, vascular and/or endothelial function at a cellular level with relevant applications in ...
Giuseppe Rengo
core   +1 more source

Glycated hemoglobin (HbA1c) is independently associated with the bioelectrical impedance phase angle in junior sumo wrestlers: A pilot study

Physiological Reports
The study explores the relationship between phase angle (PhA), an indicator of cellular health, and metabolic health parameters among junior sumo wrestlers in Japan.
Suraiya Khatun, Miori Ogawa, Akiko Uchizawa, Daisuke Hoshi, Shinsuke Tamai, Reiko Momma, Emi Kondo, Koichi Watanabe, Hiroyuki Sagayama   +8 more
doaj   +1 more source

Biogenesis of the oxidative phosphorylation machinery in plants. From gene expression to complex assembly

, 2014
Mitochondrial biogenesis is an extremely complex process. A hint of this complexity is clearly indicated by the many steps and factors required to assemble the respiratory complexes involved in oxidative phosphorylation.
Daniel H. Gonzalez
core   +1 more source

The Evolution of Endothermy - From Patterns to Mechanisms

, 2018
Metabolic rate is a key ecophysiological factor determining fitness, distribution, survival and reproductive strategies of organisms. The ability to endogenously produce heat and elevate body temperature beyond ambient, has far reaching ecological ...
Elias T. Polymeropoulos, Rebecca Oelkrug, Martin Jastroch   +2 more
core   +1 more source

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

, 2015
The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial ...
George E. Billman
core   +1 more source

Advances in Mechanisms of Renal Fibrosis

, 2018
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a
David J. Nikolic-Paterson, Hui Y. Lan
core   +1 more source