Results 111 to 120 of about 182,594 (345)

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Journal of Pharmacological Sciences, 2005
To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs.
Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, Masami Kato, Masayoshi Shimizu, Takao Ota   +5 more
doaj   +1 more source

Clinical cardiac electrophysiologic evaluation of the positive inotropic agent, DPI 201-106 [PDF]

, 2017
DPI 201-106 is a new positive inotropic agent. The cardiac electrophysiology of 16 patients was studied before and during DPI 201-106 administration (loading dose of intravenous DPI 201-106, 1·8 mg kg−1 h−1 administered over 10 min, followed by a ...
BUTROUS, G. S., CAMM, A. J., DAVIES, D. W., DEBBAS, N. M. G., ERWIN, J., KELLER, H. P., LUNNON, M. W., NATHAN, A. W.   +7 more
core  

Spikes in quantum trajectories

, 2015
A quantum system subjected to a strong continuous monitoring undergoes quantum jumps. This very well known fact hides a neglected subtlety: sharp scale-invariant fluctuations invariably decorate the jump process even in the limit where the measurement ...
Bauer, Michel, Bernard, Denis, Tilloy, Antoine   +2 more
core   +3 more sources

Reliability of qt intervals as indicators of clinical hypercalcemia [PDF]

, 1988
Rehan Ahmed, Kunitake Hashiba
openalex   +1 more source

Freeze‐resistant, conductive semi‐interpenetrating network hydrogels enable oxidative stress regulation and enhanced wound healing

Interdisciplinary Medicine, EarlyView.
A multifunctional SFMA9/PF1 semi‐interpenetrating hydrogel with excellent conductivity, antioxidant activity, and freeze resistance effectively regulates the wound microenvironment, reduces oxidative stress and inflammation, promotes angiogenesis, and accelerates full‐thickness skin regeneration.
Xiaomin Sun, Yanqin Yu, Xinyuan He, Kaiyi Tang, Lijing Teng, Tianbao Qian, Zhu Zeng, Zuquan Hu   +7 more
wiley   +1 more source

Population Pharmacokinetics Analysis of Talazoparib and Enzalutamide Combination Therapy for Patients With Metastatic Castration‐Resistant Prostate Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract The poly(ADP‐ribose) polymerase inhibitor talazoparib, combined with the androgen receptor inhibitor enzalutamide is approved for patients with homologous recombination repair (HRR) gene‐mutated metastatic castration‐resistant prostate cancer (mCRPC) in the US and with mCRPC in whom chemotherapy is not clinically indicated in Europe.
Mark Hadigol, Jason H. Williams, Haihong Shi, Derek Z. Yang, Justin Hoffman, Diane D. Wang   +5 more
wiley   +1 more source

PS-091 Dispersion Of The Qt And Qtc Intervals-early Marker Of Anthracycline Induced Cardiotoxicity In Children With Malignant Hemopathies [PDF]

, 2014
L. Dimitriu, AG Dimitriu, Ingrith Miron, C.G. Mandric   +3 more
openalex   +1 more source

Quantitative Confounder Analysis of Electrocardiogram Signals in Cardiac Magnetic Resonance at 1.5, 3 and 7 T—Assessing Standardized Electrode Positions and Sequence Types—Towards Quality Assurance

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The electrocardiogram (ECG) used for gating in cardiac MRI may be compromised by multiple confounders inside the scanner bore. Purpose To quantify the influence of magnetic field strengths (1.5 T/3 T/7 T), standardized electrode positions, and imaging sequences on ECG signals used for gating. Study Type Prospective.
Richard Hickstein, Stephanie Wiesemann, Darian Viezzer, Denise Kleindienst, Teodora Chitiboi, Bogdan Andrei Gheorghita, Jens Wetzl, Thomas Hadler, Sebastian Dietrich, Sebastian Schmitter, Jeanette Schulz‐Menger   +10 more
wiley   +1 more source

Short QT interval

Health Renaissance, 2013
Introduction: Short QT Interval (Short QT Syndrome) is a very rare clinical condition. An individual with short QT interval frequently presents with chest pain, palpitation, fainting attack and sometimes cardiac death. Objective: To report a case of Short QT Syndrome. Case: A 27 year old man presented with the complaint of frequent attack of chest pain,
openaire   +2 more sources

Hepatopulmonary syndrome in children and adolescents with portal hypertension in Brazil: A multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To describe the clinical and laboratory characteristics and outcomes of pediatric hepatopulmonary syndrome (HPS) secondary to portal hypertension (PH) in Brazil. Methods Fifty‐four pediatric patients diagnosed with PH and HPS according to the European Respiratory Society criteria were included in this multicenter retrospective study.
Leticia Drumond Alberto, Eleonora Druve Tavares Fagundes, Adriana Teixeira Rodrigues, Thaís Costa Nascentes Queiroz, Gustavo Valverde de Castro, Carlos Oscar Kieling, Sandra Maria Gonçalves Vieira, Natália Lamounier dos Martires Guerra, Natascha Silva Sandy, Gilda Porta, Irene Kazue Miura, Maria Ângela Bellomo Brandão, Gabriel Hessel, Adriana Maria Alves de Tommaso, Alexandre Rodrigues Ferreira   +14 more
wiley   +1 more source