Results 111 to 120 of about 180,206 (347)

QT interval in healthy dogs: which method of correcting the QT interval in dogs is appropriate for use in small animal clinics?

Pesquisa Veterinária Brasileira, 2014
The electrocardiography (ECG) QT interval is influenced by fluctuations in heart rate (HR) what may lead to misinterpretation of its length. Considering that alterations in QT interval length reflect abnormalities of the ventricular repolarisation which ...
Maira S. Oliveira, Ruthnéa A.L. Muzzi, Leonardo A.L. Muzzi, Marcos Cherem, Matheus M. Mantovani   +4 more
doaj   +1 more source

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin, Johann Bauersachs, Magdy Abdelhamid, Suleman Aktaa, Hussam Al Ghorani, Antonio Bayes‐Genis, Jan Biegus, Michael Böhm, Javed Butler, Nicolas Girerd, Marco Metra, Wilfried Mullens, Hadi Skouri, Muthiah Vaduganathan, Seif El Hadidi, Giuseppe M.C. Rosano, Gianluigi Savarese   +16 more
wiley   +1 more source

Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609(Cipargamin) and Piperaquine [PDF]

, 2015
KAE609 represents a new class of potent, fast-acting, schizonticidal antimalarials. This study investigated the safety and pharmacokinetics of KAE609 in combination with the long-acting antimalarial piperaquine (PPQ) in healthy volunteers.
Griffin, Paul, Jain, Jay Prakash, Kangas, Michael, Lefèvre, Gilbert, Lickliterf, Jason, Machineni, Surendra, Stein, Daniel S   +6 more
core   +1 more source

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals [PDF]

, 2018
Nathan A. Bihlmeyer, Jennifer A. Brody, Albert V. Smith, Helen R. Warren, Honghuang Lin, Aaron Isaacs, Ching‐Ti Liu, Jonathan Marten, Farid Radmanesh, Leanne M. Hall, Niels Grarup, Hao Mei, Martina Müller‐Nurasyid, Jennifer E. Huffman, Niek Verweij, Xiuqing Guo, Jie Yao, Ruifang Li‐Gao, Marten van den Berg, Stefan Weiß, Bram P. Prins, Jessica van Setten, Jeffrey Haessler, Leo‐Pekka Lyytikäinen, Man Li, Álvaro Alonso, Elsayed Z. Soliman, Joshua C. Bis, Tom Austin, Yii-Der Ida Chen, Bruce M. Psaty, Tamara B. Harrris, Lenore J. Launer, Sandosh Padmanabhan, Anna F. Dominiczak, Paul L. Huang, Zhijun Xie, Patrick T. Ellinor, Jan A. Kors, Archie Campbell, Alison D. Murray, Christopher P. Nelson, Martin D. Tobin, Jette Bork‐Jensen, Torben Hansen, Oluf Pedersen, Allan Linneberg, Moritz F. Sinner, Annette Peters, Mélanie Waldenberger, Thomas Meitinger, Siegfried Perz, Ivana Kolčić, Igor Rudan, Rudolf A. de Boer, Peter van der Meer, Henry J. Lin, Kent D. Taylor, Renée de Mutsert, Stella Trompet, J. Wouter Jukema, Arie C. Maan, Bruno H. Stricker, Fernando Rivadeneira, André G. Uitterlinden, Uwe Völker, Georg Homuth, Henry Völzke, Stephan B. Felix, Massimo Mangino, Timothy D. Spector, Michiel L. Bots, Marco Perez, Olli T. Raitakari, Mika Kähönen, Nina Mononen, Vilmundur Guðnason, Patricia B. Munroe, Steven A. Lubitz, Cornelia M. van Duijn, Christopher Newton‐Cheh, Caroline Hayward, Jonathan Rosand, Nilesh J. Samani, Jørgen K. Kanters, James G. Wilson, Stefan Kääb, Ozren Polašek, Pim van der Harst, Susan R. Heckbert, Jerome I. Rotter, Dennis O. Mook‐Kanamori, Mark Eijgelsheim, Marcus Dörr, Yalda Jamshidi, Folkert W. Asselbergs, Charles Kooperberg, Terho Lehtimäki, Dan E. Arking, Nona Sotoodehnia   +99 more
openalex   +1 more source

Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic–clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)‐based cross‐frequency phase–amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non‐SUDEP
Adam C. Gravitis, Richard Wennberg, Peter L. Carlen, Yotin Chinvarun, Victor Lira, Juliana Laze, Orrin Devinsky, Berj L. Bardakjian   +7 more
wiley   +1 more source

QT PRODACT: In Vivo QT Assay in the Conscious Dog for Assessing the Potential for QT Interval Prolongation by Human Pharmaceuticals

Journal of Pharmacological Sciences, 2005
The goal of the present study was to examine the utility of the conscious dog model by assessing the QT-interval-prolonging potential of ten positive compounds that have been reported to induce QT interval prolongation in clinical use and seven negative ...
Shigeki Toyoshima, Akihiro Kanno, Tetsuya Kitayama, Koji Sekiya, Keiko Nakai, Masao Haruna, Terumasa Mino, Hiroyasu Miyazaki, Koji Yano, Keiji Yamamoto   +9 more
doaj   +1 more source

Clinical cardiac electrophysiologic evaluation of the positive inotropic agent, DPI 201-106 [PDF]

, 2017
DPI 201-106 is a new positive inotropic agent. The cardiac electrophysiology of 16 patients was studied before and during DPI 201-106 administration (loading dose of intravenous DPI 201-106, 1·8 mg kg−1 h−1 administered over 10 min, followed by a ...
BUTROUS, G. S., CAMM, A. J., DAVIES, D. W., DEBBAS, N. M. G., ERWIN, J., KELLER, H. P., LUNNON, M. W., NATHAN, A. W.   +7 more
core  

Prolonged Corrected QT Interval in Patients with Myotonic Dystrophy Type 1 [PDF]

, 2013
Kang Min Park, Kyong Jin Shin, Sung Eun Kim, Jinse Park, Sam Yeol Ha, Byoung Joon Kim   +5 more
openalex   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Tp–e interval and Tp–e/QT ratio in patients with Human Immunodeficiency Virus

Journal of Infection and Public Health, 2018
Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias.
Sefa Ünal, Çağrı Yayla, Burak Açar, Ahmet G. Ertem, Mehmet K. Akboğa, Serkan Gökaslan, Mehmet A. Erdöl, Meliha Ç. Sönmezer, Esra Kaya Kiliç, Çiğdem Ataman Hatipoğlu, Necla Tulek, Fatma S. Erdinç, Sinan Aydoğdu, Ahmet Temizhan   +13 more
doaj   +1 more source