Results 91 to 100 of about 51,415 (237)

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Journal of Pharmacological Sciences, 2005
To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs.
Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, Masami Kato, Masayoshi Shimizu, Takao Ota   +5 more
doaj   +1 more source

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach

iNew Medicine, EarlyView.
Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma, Sushma Verma, Mohammad Abbas, Tabrez Faruqui, Bashir Ahmad Mir, Farzana Mahdi   +5 more
wiley   +1 more source

LINC01605 Predicts the Poor Prognosis of Non‐Small Cell Lung Cancer and Promotes Chemotherapy Resistance by Regulating miR‐7111‐5p/ELK1

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Non‐small cell lung cancer (NSCLC) is characterized by high incidence, mortality, and poor patient prognosis, with chemotherapy resistance being a common challenge. This research intends to identify key molecules involved in NSCLC and elucidate the regulatory role of the LINC01605/miR‐7111‐5p/ELK1 axis in chemotherapy resistance. LINC01605 and
Fang Zhang, Zhi‐Liang Yang, Tian‐Tian Qin, Guo‐Jun Zhang, Xiang Li   +4 more
wiley   +1 more source

Congenital Short QT Syndrome

Indian Pacing and Electrophysiology Journal, 2004
Long QT intervals in the ECG have long been associated with sudden cardiac death. The congenital long QT syndrome was first described in individuals with structurally normal hearts in 1957.1 Little was known about the significance of a short QT ...
Charles Antzelevitch, Johnson Francis
doaj  

Smaller hamstrings autograft size after primary ACL reconstruction is associated with higher odds for graft failure: A meta‐analysis on autografts sizes covering 46,268 patients

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To investigate the association between autograft size and graft failure for hamstrings tendon (HT), patellar tendon (PT) and quadriceps tendon (QT) autografts. Methods Medline, PubMed, Cochrane Library, Embase, Amed and Web of Science were searched at four separate time points, with the most recent search in February 2025.
Rebecca Hamrin Senorski, Johan Högberg, Kevin Teow, Anna Nordenholm, Janina Kaarre, Thorkell Snaebjörnsson, Volker Musahl, Kristian Samuelsson, Eric Hamrin Senorski   +8 more
wiley   +1 more source

Inferior clinical outcomes and higher subjective treatment failure after revision compared to primary posterior cruciate ligament reconstruction: A propensity score‐matched analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare subscales of the Knee injury and Osteoarthritis Outcome Score (KOOS), concomitant injuries and failure rates between patients undergoing primary and revision posterior cruciate ligament reconstruction (PCLR). Methods This study was based on three major Scandinavian knee ligament registries (Sweden, Norway, Denmark). Patients
Philipp Wilhelm Winkler, Bálint Zsidai, Eric Narup, Armin Runer, Martin Lind, Gilbert Moatshe, Eric Hamrin Senorski, Volker Musahl, Kristian Samuelsson   +8 more
wiley   +1 more source

Impact of hamstring versus quadriceps tendon graft on thigh muscle strength and surface electromyography activity after anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare quadriceps tendon (QT) and hamstring tendon (HT) autografts regarding isometric thigh muscle strength, surface electromyography (sEMG) activity and clinical outcomes following anterior cruciate ligament reconstruction (ACLR).
Benjamin Forquignon, Tobias Drenck, Matthias Krause, Ralph Akoto, Karl‐Heinz Frosch, Götz Welsch, Alexander Korthaus, Grégoire Thürig, Dimitris Dalos   +8 more
wiley   +1 more source

A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS

Frontiers in Cardiovascular Medicine
PurposeTo identify the most commonly reported drugs associated with QT interval prolongation in the FDA Adverse Event Reporting System (FAERS) and evaluate their risk for QT interval prolongation.MethodsWe employed the preferred term (PT ...
Haowen Tan, Haowen Tan, Xida Yan, Ying Chen, Guili Huang, Luping Luo, Wenjun Li, Weiwei Lan, Cheng Chen, Xin Xi   +9 more
doaj   +1 more source

Quadriceps tendon autograft is not inferior to bone‐patellar tendon‐bone or hamstring autograft in anterior cruciate ligament reconstruction in terms of subjective patient‐reported outcomes: Two‐year results of a multicenter randomised controlled study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the effectiveness of quadriceps tendon (QT) compared to bone‐patellar tendon‐bone (BPTB) and hamstring tendon (HT) autografts in anterior cruciate ligament reconstruction (ACLR) regarding patient‐reported outcomes 2 years postoperatively.
Barbara C. Boer, Reinoud W. Brouwer, Judith olde Heuvel, Astrid J. de Vries, Wybren A. van der Wal, J. Christiaan Rompen, Albert H. van Houten, Roy A. G. Hoogeslag   +7 more
wiley   +1 more source