A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS [PDF]
Frontiers in Cardiovascular MedicinePurposeTo identify the most commonly reported drugs associated with QT interval prolongation in the FDA Adverse Event Reporting System (FAERS) and evaluate their risk for QT interval prolongation.MethodsWe employed the preferred term (PT ...
Haowen Tan +9 more
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Association Between Disturbed Serum Phosphorus Levels and QT Interval Prolongation [PDF]
Kidney International ReportsIntroduction: QT interval prolongation is a risk factor for fatal arrhythmias and other cardiovascular complications. QT interval prolongation in patients on hemodialysis (HD) is not well understood.
Sho Sasaki +6 more
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Prevalence of the QT interval prolongation and its risk factors in hospitalized geriatric patients: findings of a single center cross-sectional study in Pakistan [PDF]
BMC GeriatricsBackground and objectives Geriatric inpatients are particularly susceptible to Torsades de Pointes (TdP) because they are usually polymorbid and often take QT-prolonging drugs.
Huma Tanveer +9 more
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A case with a trend of QT interval prolongation due to the introduction of methadone to a pancreatic cancer patient on levofloxacin [PDF]
Journal of Pharmaceutical Health Care and SciencesBackground As methadone can prevent the development of opioid resistance, it has application in alleviating cancer-related pain that proves challenging to manage with other opioids. QT interval prolongation is a serious side effect of methadone treatment,
Ryusuke Ouchi +9 more
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Effect of QT interval-prolonging drugs taken in pregnancy on the neonatal QT interval
Frontiers in Pharmacology, 2023 Introduction: Acquired QT interval prolongations due to drug side effects can result in detrimental arrhythmia. Maternal use of placenta-permeable drugs may lead to fetal exposure, thus leading to an increased risk of neonatal QT prolongation and ...
Holger Michel +13 more
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Drug-induced QT interval prolongation in patients with heart failure with preserved ejection fraction. [PDF]
PLoS ONEHeart failure (HF) with reduced ejection fraction (HFrEF) is a risk factor for drug-induced QT interval prolongation. It is unknown if HF with preserved ejection fraction (HFpEF) is also associated with an increased risk.
Chien-Yu Huang +5 more
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Journal of the Formosan Medical Association, 2023 Background: Fluoroquinolones, crucial components of treatment regimens for drug-resistant tuberculosis (TB), are associated with QT interval prolongation and risks of fatal cardiac arrhythmias. However, few studies have explored dynamic changes in the QT
Ke-Shiuan Ju +8 more
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Bedaquiline Correlation to QT Interval Prolongation in DR-TB Patients
Jurnal Respirasi, 2022 Introduction: The regimen of drug-resistant tuberculosis (DR-TB) is Bedaquiline. One of the adverse events is QT interval prolongation, which can increase the risk of Torsade de Pointes (TdP) and lead to death. DR-TB patient screening before starting the
Vandu Primadana +2 more
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CLINICAL SIGNIFICANCE OF DRUGINDUCED INTERVALS QT AND QTC PROLONGATION
Рациональная фармакотерапия в кардиологии, 2015 Interval QT prolongation is a predictor of the life-threatening cardiac arrhythmias — polymorphic ventricular tachycardia (torsade de pointes). Long QT syndrome may be congenital or acquired.
N. V. Furman, S. S. Shmatova
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Prolongation of the QT interval by ketanserin [PDF]
Postgraduate Medical Journal, 1988 Summary In hypertensive patients single doses of ketanserin 40 mg prolonged the corrected QT interval (QTc) for at least 8 hours, with a maximal increase of 35 ms (P less than 0.001, n = 6) after 2 hours. During chronic dosing (20 and 40 mg b.d.) the QTc was further prolonged, by 46 and 45 ms respectively.
H A, Cameron, P C, Waller, L E, Ramsay
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