Results 11 to 20 of about 39,180 (240)

Prolongation of the QT interval by ketanserin [PDF]

Postgraduate Medical Journal, 1988
Summary In hypertensive patients single doses of ketanserin 40 mg prolonged the corrected QT interval (QTc) for at least 8 hours, with a maximal increase of 35 ms (P less than 0.001, n = 6) after 2 hours. During chronic dosing (20 and 40 mg b.d.) the QTc was further prolonged, by 46 and 45 ms respectively.
H A, Cameron, P C, Waller, L E, Ramsay
openaire   +2 more sources

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +1 more source

Trigger versus Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator [PDF]

, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Antzelevitch, Antzelevitch, Benson, Benson, Benson, Benson, Bezekci, Bilet, Bohnen, Camm, Campos, Clancy, Clayton, Clusin, Colman, Colman, Drouin, Dutta, Glukhov, Grunnet, Guo, Hansen, Hart, Janse, Kalin, Kléber, Kumar, Lankipalli, Li, Lou, Mann, Mirams, Moss, Nachimuthu, Noble, Němec, O'Hara, Pandit, Peitersen, Perez Alday, Perez Alday, Perez Alday, Ratner, Restrepo, Rush, Schwartz, Shaw, Smaill, Starmer, Strom, ten Tusscher, Tomaselli, Tse, Venetucci, Vinet, Wagner, Walton, Wu   +57 more
core   +2 more sources

A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. [PDF]

, 2017
Background -Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications.
Behr, ER, Blinova, K, Johannesen, L, Kosova, G, Mason, JW, Newton-Cheh, C, Roden, DM, Rosenberg, MA, Strauss, DG, Vicente, J, Weeke, P, Woosley, R   +11 more
core   +2 more sources

Beyond a prolonged QT interval

JRSM Short Reports, 2013
A hypocalcaemia case is presented with convulsions, electrocardiogram (ECG) changes and laboratory findings suggestive of osteomalacia. This case constitutes a rare presentation of osteomalacia-induced hypocalcaemia.
Bitar, Zouheir Ibrahim, Maadarani, Ossama, Alfayed, Hani, Bitar, Mohammed   +3 more
openaire   +2 more sources

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

QT peak prolongation predicts cardiac death following stroke [PDF]

, 2015
Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak.
Douglas, Denise, Fraser, Hazel W, MacWalter, Ronald S, Ogston, Simon A, Struthers, Allan D, Suich, Joseph, Wong, Kenneth Y K, Wong, Suzanne Y S   +7 more
core   +1 more source

Prolonged QT interval in Rett syndrome [PDF]

Archives of Disease in Childhood, 1999
Rett syndrome is a severe neurodevelopmental disorder of unknown aetiology. A prolonged QT interval has been described previously in patients with Rett syndrome. To investigate QT prolongation and the presence of cardiac tachyarrhythmias in Rett syndrome electrocardiography and 24 hour Holter monitoring were performed prospectively in a cohort of 34 ...
C J, Ellaway, G, Sholler, H, Leonard, J, Christodoulou   +3 more
openaire   +2 more sources

Corrected QT Interval in Children With Brain Death [PDF]

, 2010
Prolongation of the QT interval is a well-documented finding in adults with severe brain injury. However, QT prolongation has not been well documented in the pediatric population with brain injury. Our objective was to determine the range of QT intervals
Jennifer Plymale, Jeanny Park, JoAnne Natale, Anita Moon-Grady   +3 more
core   +2 more sources

Prolonged QT Interval: A Tricky Diagnosis? [PDF]

The American Journal of Cardiology, 1997
Prolonged heart-rate adjusted QT intervals on the electrocardiogram (ECG) are associated with an increased risk for coronary heart disease and sudden death. However, the diagnosis of the prolonged QT interval is hampered by lack of standards. We studied variations in the prevalence of prolonged QT, based on different common definitions, in a large ...
M C, de Bruyne, A W, Hoes, J A, Kors, J M, Dekker, A, Hofman, J H, van Bemmel, D E, Grobbee   +6 more
openaire   +2 more sources