Results 121 to 130 of about 1,993,809 (355)

Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent Klebsiella pneumoniae

open access: yesiMeta, EarlyView.
The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu   +15 more
wiley   +1 more source

Effects of hydroxychloroquine treatment on QT interval

open access: yesHeart Rhythm, 2020
Matthew Hooks   +4 more
semanticscholar   +1 more source

Phenothiazine Derivatives and Their Impact on the Apoptosis Processes: A Review

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Phenothiazine derivatives have been used for decades as antipsychotic drugs in multiple mental health and physical conditions treatment (schizophrenia, mania in bipolar disorder, and psychosis). Epidemiological studies have shown that people with schizophrenia are less likely to suffer from cancer, which indicates the ability of antipsychotics
Michał Otręba   +4 more
wiley   +1 more source

Assessment of the Effects of Fruquintinib on Cardiac Safety in Patients with Metastatic Colorectal Cancer

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib is a highly selective oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, approved by the US Food and Drug Administration and the European Commission for the treatment of previously treated metastatic colorectal cancer (mCRC), regardless of biomarker status. This study used concentration QT interval (C‐QTc)
Xiaofei Zhou   +7 more
wiley   +1 more source

Sorption and desorption behavior of hydroxychloroquine and ivermectin in WWTP sludge: kinetic and equilibrium insights

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Domestic sewage is one of the main pathways for the introduction of pharmaceutical contaminants into environmental compartments. During the COVID‐19 pandemic, the consumption of medications such as hydroxychloroquine (HCQ) and ivermectin (IVM) increased significantly, resulting in a greater presence of these substances in ecosystems.
Bruna Giovana Locatelli   +3 more
wiley   +1 more source

Sonographic Patellar and Quadriceps Tendon Length Pre‐ and Post‐Autograft Harvest: Reliability and Concurrent Validity

open access: yesJournal of Orthopaedic Research, EarlyView.
ABSTRACT Extensor mechanism autografts used for anterior cruciate ligament reconstruction, namely bone‐patellar tendon‐bone (BPTB) and quadriceps tendon (QT), may result in harvest‐site tendon elongation. Extended field of view (EFOV) ultrasound imaging has the potential to evaluate changes in tendon length, but the reliability and validity of these ...
Andrew Sprague, George Raum, Naoaki Ito
wiley   +1 more source

OBSERVATIONS ON THE CHANGE OF VENTRICULAR SYSTOLE (QT INTERVAL) DURING EXERCISE 1

open access: bronze, 1950
Paul N. Yu   +3 more
openalex   +1 more source

Prolongation of the QT interval in children with liver failure [PDF]

open access: bronze, 1999
Steven B. Fishberger   +2 more
openalex   +1 more source

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