Results 141 to 150 of about 51,415 (237)

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Dynamic evaluation of serum atherogenic factors as a predictor of QT interval prolongation in patients with type 2 diabetes mellitus. [PDF]

Am J Transl Res
Su M, Qiu Y, Zhu Y, Hou W, Yao J, Qu X, Liu J.   +6 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

QT Interval Prolongation in Chronic Liver Disease: A Cross-Sectional Study. [PDF]

Cureus
Venkata Harischandra T, Zulqurnain A, Irshad A, Arif M, Abdul Razzak A, Tayyab M, Rehman AU.   +6 more
europepmc   +1 more source

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

Cancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba, Toshihiro Miyamoto, Senji Kasahara, Yoshikane Kikushige, Takahiro Maeda, Goichi Yoshimoto, Shuichi Ota, Akio Saito, Yuho Najima, Hiroki Hosoi, Daigo Niiya, Koji Kato, Koji Nagafuji, Takashi Akasaka, Tomohiko Kamimura, Atsushi Takita, Maiko Narahara, Tadashi Toki, Koichi Iwanaga, Koji Yonemoto, Mine Harada, Koichi Akashi   +21 more
wiley   +1 more source

QTcNet: a deep learning model for direct heart rate corrected QT interval estimation. [PDF]

Europace
Plagwitz L, Doldi F, Magerfleisch J, Zotov M, Bickmann L, Heider D, Varghese J, Eckardt L, Büscher A.   +8 more
europepmc   +1 more source

Incentives and motivational crowding to address chronic wasting disease: An experiment with Alberta hunters

Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie, EarlyView.
Abstract Behavioral interventions, for example, through the use of incentives and information, are widely used by policymakers to induce welfare‐improving behavior. When these interventions are used in specific contexts such as environmental conservation, individual knowledge, experience, and attitudes can lead to motivational crowding and may limit ...
Lusi Xie, Maik Kecinski, Wiktor Adamowicz   +2 more
wiley   +1 more source

Epidemiology and related risk factors of prolonged QT interval in neonates. [PDF]

Pak J Med Sci
Hong Y, Wang Y, Zhou Q, Wang M, Zhou J.
europepmc   +1 more source

What we know about wildlife outcomes of the conservation reserve program: A meta‐analysis

Conservation Science and Practice, EarlyView.
Abstract The Conservation Reserve Program (CRP) is one of the most extensive private‐land conservation programs in the United States, aimed at mitigating habitat loss and supporting biodiversity in agricultural landscapes. Individual studies of CRP effects on wildlife report mixed results, necessitating a comprehensive synthesis.
M. P. Nessel, E. V. Lassiter, C. J. Duchardt, K. Maguire, J. E. Diffendorfer, R. Iovanna, S. R. Loss   +6 more
wiley   +1 more source