Results 21 to 30 of about 182,594 (345)

Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]

, 2012
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...
Arking, Dan E., Asselbergs, Folkert W., Brown, Morris, Carter, Nicholas D., Caulfield, Mark, Connell, John, Dalageorgou, Chrysoula, de Bakker, Paul I Wen, Deloukas, Panos, Dominiczak, Anna, Eijgelsheim, Mark, Farrall, Martin, Fu, Jingyuan, Gwilliam, Rhian, Jamshidi, Yalda, Jeffery, Steve, Lathrop, Mark, Munroe, Patricia B., Newhouse, Stephen J., Newton-Cheh, Christopher Holmes, Nolte, Ilja M., Paterson, Andrew D., Pfeufer, Arne, Rice, Kenneth Robert, Samani, Nilesh J., Sanna, Serena, Savelieva, Irina, Snieder, Harold, Soranzo, Nicole, Spector, Tim D., Tobin, Martin, Waggott, Daryl, Wain, Louise V., Wallace, Chris, Zeggini, Eleftheria, Zheng, Dongling   +35 more
core   +1 more source

QT Indexes in Cirrhotic Patients: Relationship with Clinical Variables and Potential Diagnostic Predictive Value. [PDF]

, 2015
BACKGROUND AND AIMS: A wide spectrum of cardiovascular changes characterizes cirrhosis, ranging from subclinical alterations to hyperkinetic syndrome.
BUTTA', Carmelo, CASUCCIO, Alessandra, CIRRINCIONE, Anna, D'AGUANNO, Gisella, DI RAIMONDO, Domenico, GIARRUSSO, Lucia, Miceli, G., Pecoraro, R., PINTO, Antonio, Renda, C., Serio, A., TUTTOLOMONDO, Antonino   +11 more
core   +1 more source

Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third National Health and Nutrition Examination Survey. [PDF]

PLoS ONE, 2011
Abnormalities in the electrocardiographic QT interval duration have been associated with an increased risk of ventricular arrhythmias and sudden cardiac death.
Yiyi Zhang, Wendy S Post, Darshan Dalal, Elena Blasco-Colmenares, Gordon F Tomaselli, Eliseo Guallar   +5 more
doaj   +1 more source

Prolonged QT interval: A tricky diagnosis? [PDF]

, 1997
Prolonged heart-rate adjusted QT intervals on the electrocardiogram (ECG) are associated with an increased risk far coronary heart disease and sudden death. However, the diagnosis of the prolonged QT interval is hampered by lack of standards.
Bemmel, J.H. (Jan) van, Bruyne, M.C. (Martine) de, Dekker, J.M. (Jacqueline), Grobbee, D.E. (Diederick), Hoes, A.W. (Arno), Hofman, A. (Albert), Kors, J.A. (Jan)   +6 more
core   +1 more source

Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects

Frontiers in Physiology, 2022
While it is now well-understood that the extent of QT interval changes due to underlying heart rate differences (i.e., the QT/RR adaptation) needs to be distinguished from the speed with which the QT interval reacts to heart rate changes (i.e., the so ...
Irena Andršová, Katerina Hnatkova, Martina Šišáková, Ondřej Toman, Peter Smetana, Katharina M. Huster, Petra Barthel, Tomáš Novotný, Georg Schmidt, Marek Malik, Marek Malik   +10 more
doaj   +1 more source

A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. [PDF]

, 2017
Background -Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications.
Behr, ER, Blinova, K, Johannesen, L, Kosova, G, Mason, JW, Newton-Cheh, C, Roden, DM, Rosenberg, MA, Strauss, DG, Vicente, J, Weeke, P, Woosley, R   +11 more
core   +2 more sources

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly. [PDF]

, 2015
Cardiovascular diseases, including ventricular arrhythmias are responsible for increased mortality in patients with acromegaly. Acromegaly may cause repolarization abnormalities such as QT prolongation and impairment of repolarization reserve enhancing ...
Baczkó, István, Csajbók, Éva, Czekus, C., Forster, Tamás, Gavaller, H., Lengyel, Csaba Attila, Magony, Sándor, Nemes, Attila, Orosz, Andrea, Papp, Gyula, Valkusz, Zsuzsanna, Varró, András, Várkonyi, Tamás, Wittmann, Tibor   +13 more
core   +10 more sources

Evaluation of differences in automated QT/QTc measurements between Fukuda Denshi and Nihon Koden systems. [PDF]

PLoS ONE, 2014
Automatic measurement becomes a preference, and indeed a necessity, when analyzing 1000 s of ECGs in the setting of either drug-inducing QT prolongation screening or genome-wide association studies of QT interval.
Motoaki Sano, Yoshiyasu Aizawa, Yoshinori Katsumata, Nobuhiro Nishiyama, Seiji Takatsuki, Shigeo Kamitsuji, Naoyuki Kamatani, Keiichi Fukuda   +7 more
doaj   +1 more source

Bedaquiline Correlation to QT Interval Prolongation in DR-TB Patients

Jurnal Respirasi, 2022
Introduction: The regimen of drug-resistant tuberculosis (DR-TB) is Bedaquiline. One of the adverse events is QT interval prolongation, which can increase the risk of Torsade de Pointes (TdP) and lead to death. DR-TB patient screening before starting the
Vandu Primadana, Indra Yovi, Dyah Siswanti Estiningsih   +2 more
doaj   +1 more source