Results 41 to 50 of about 181,524 (344)

Validation of automatic measurement of QT interval variability [PDF]

, 2017
Background Increased variability of beat-to-beat QT-interval durations on the electrocardiogram (ECG) has been associated with increased risk for fatal and non-fatal cardiac events. However, techniques for the measurement of QT variability (QTV) have not
Berg, M.E. (Marten) van den, Herpen, G. (Gerard) van, Kors, J.A. (Jan), Rijnbeek, P.R. (Peter), Ritsema Van Eck, H.J. (Henk J.)   +4 more
core   +10 more sources

The effects of peritoneal dialysis on QT interval in ESRD patients

BMC Nephrology, 2022
Background Patients with chronic kidney disease (CKD) are at a high risk of fatal arrhythmias. The extended corrected QT (QTc) interval is a hallmark of ventricular arrhythmias and sudden cardiac death.
Wenjing Zhang, Yu Liang, Jia Lv, Yan Li, Jiping Sun   +4 more
doaj   +1 more source

Effect of QT interval-prolonging drugs taken in pregnancy on the neonatal QT interval

Frontiers in Pharmacology, 2023
Introduction: Acquired QT interval prolongations due to drug side effects can result in detrimental arrhythmia. Maternal use of placenta-permeable drugs may lead to fetal exposure, thus leading to an increased risk of neonatal QT prolongation and ...
Holger Michel, Antonia Potapow, Markus-Johann Dechant, Susanne Brandstetter, Susanne Brandstetter, Sven Wellmann, Angela Köninger, Michael Melter, Michael Melter, Christian Apfelbacher, Michael Kabesch, Michael Kabesch, Stephan Gerling, the KUNO-Kids study group   +13 more
doaj   +1 more source

Measurement and interpretation of electrocardiographic QT intervals in murine hearts. [PDF]

, 2014
Alterations in ECG QT intervals correlate with the risk of potentially fatal arrhythmias, for which transgenic murine hearts are becoming increasingly useful experimental models. However, QT intervals are poorly defined in murine ECGs.
Fraser, James A, Huang, Christopher L-H, King, James H, Wu, JingJing, Zhang, Yanmin   +4 more
core   +2 more sources

Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

Hepatology, EarlyView., 2022
Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel, Li‐Ting Li, Huiyu She, Jian‐She Wang, Melissa A. Gilbert, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz‐Miedzińska, Emmanuel M. Gonzales, Emmanuel Jacquemin, Jérôme Bouligand, Nancy B. Spinner, Kathleen M. Loomes, David A. Piccoli, Lorenzo D'Antiga, Emanuele Nicastro, Étienne Sokal, Tanguy Demaret, Noelle H. Ebel, Jeffrey A. Feinstein, Rima Fawaz, Silvia Nastasio, Florence Lacaille, Dominique Debray, Henrik Arnell, Björn Fischler, Susan Siew, Michael Stormon, Saul J. Karpen, Rene Romero, Kyung Mo Kim, Woo Yim Baek, Winita Hardikar, Sahana Shankar, Amin J. Roberts, Helen M. Evans, M. Kyle Jensen, Marianne Kavan, Shikha S. Sundaram, Alexander Chaidez, Palaniswamy Karthikeyan, Maria Camila Sanchez, Maria Lorena Cavalieri, Henkjan J. Verkade, Way Seah Lee, James E. Squires, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Catherine Larson‐Nath, Yael Mozer‐Glassberg, Cigdem Arikan, Henry C. Lin, Jesus Quintero Bernabeu, Seema Alam, Deirdre A. Kelly, Elisa Carvalho, Cristina Targa Ferreira, Giuseppe Indolfi, Ruben E. Quiros‐Tejeira, Pinar Bulut, Pier Luigi Calvo, Zerrin Önal, Pamela L. Valentino, Dev M. Desai, John Eshun, Maria Rogalidou, Antal Dezsőfi, Sabina Wiecek, Gabriella Nebbia, Raquel Borges Pinto, Victorien M. Wolters, María Legarda Tamara, Andréanne N. Zizzo, Jennifer Garcia, Kathleen Schwarz, Marisa Beretta, Thomas Damgaard Sandahl, Carolina Jimenez‐Rivera, Nanda Kerkar, Jernej Brecelj, Quais Mujawar, Nathalie Rock, Cristina Molera Busoms, Wikrom Karnsakul, Eberhard Lurz, Ermelinda Santos‐Silva, Niviann Blondet, Luis Bujanda, Uzma Shah, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, The Global ALagille Alliance (GALA) Study Group   +93 more
wiley   +1 more source

Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609(Cipargamin) and Piperaquine [PDF]

, 2015
KAE609 represents a new class of potent, fast-acting, schizonticidal antimalarials. This study investigated the safety and pharmacokinetics of KAE609 in combination with the long-acting antimalarial piperaquine (PPQ) in healthy volunteers.
Griffin, Paul, Jain, Jay Prakash, Kangas, Michael, Lefèvre, Gilbert, Lickliterf, Jason, Machineni, Surendra, Stein, Daniel S   +6 more
core   +1 more source

QT PRODACT: In Vivo QT Assay With a Conscious Monkey for Assessment of the Potential for Drug-Induced QT Interval Prolongation

Journal of Pharmacological Sciences, 2005
In safety pharmacology studies, the effects on the QT interval of electrocardiograms are routinely assessed using a telemetry system in cynomolgus monkeys. However, there is a lack of integrated databases concerning in vivo QT assays in conscious monkeys.
Kentaro Ando, Toshiyasu Hombo, Akihiro Kanno, Hironobu Ikeda, Masakazu Imaizumi, Noritsugu Shimizu, Kengo Sakamoto, Shin-ichi Kitani, Yoshinori Yamamoto, Shingo Hizume, Keiko Nakai, Tetsuya Kitayama, Keiji Yamamoto   +12 more
doaj   +1 more source

Thoracic epidural analgesia prolongs postoperative QT interval on electrocardiogram in major non-cardiac surgery: a randomized comparison and a prospective cohort analysis

Frontiers in Pharmacology, 2023
Introduction: Prolongation of QT interval on electrocardiogram can be associated with perioperative lethal arrhythmia. Epidural analgesia is a commonly used modality to relieve surgical pain by blocking sensory nerves, which also blocks the autonomic ...
Kotaro Hori, Shogo Tsujikawa, Mika Egami, Sayaka Waki, Ryota Watanabe, Hideki Hino, Tadashi Matsuura, Takashi Mori   +7 more
doaj   +1 more source

In silico investigation of a KCNQ1 mutation associated with short QT syndrome [PDF]

, 2017
Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death.
A El Harchi, A Mazzanti, C Antzelevitch, C Bellocq, C Giustetto, C Giustetto, C Lerche, C Moreno, C Patel, C Templin, DG Whittaker, DL Weiss, F Gaita, H Watanabe, H Zhang, I Adeniran, I Gussak, J Barhanin, J Silva, JA Nelder, K Gima, K Hong, KHWJ Tusscher, KHWJ Tusscher Ten, KHWJten Tusscher, L Priebe, L Restier, MC Sanguinetti, MJ Curtis, MP Nash, O Anttonen, P Bjerregaard, P Maury, R Schimpf, R Schimpf, R Schimpf, R Schimpf, R Schimpf, R Towart, RH Clayton, RH Keldermann, RS Duncan, S Frea, T O’Hara, Z-J Wu   +44 more
core   +4 more sources

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source