Results 51 to 60 of about 181,524 (344)

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen family study [PDF]

, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies of ...
Amin, N. (Najaf), Axenovich, T.I. (Tatiana), Berg, M.E. (Marten) van den, Demirkan, A. (Ayşe), Duijn, C.M. (Cornelia) van, Isaacs, A.J. (Aaron), Kirichenko, A.V. (Anatoly), Kors, J.A. (Jan), Leeuwen, E.M. (Elisa) van, Oostra, B.A. (Ben), Silva Aldana, C.T. (Claudia), Stricker, B.H.Ch. (Bruno), Uitterlinden, A.G. (André), Willemsen, R. (Rob), Witteman, J.C.M. (Jacqueline), Zorkoltseva, I.V. (Irina)   +15 more
core   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Journal of Pharmacological Sciences, 2019
Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation.
Petr Vesely, Tibor Stracina, Miroslava Hlavacova, Josef Halamek, Jana Kolarova, Veronika Olejnickova, Veronika Mrkvicova, Hana Paulova, Marie Novakova   +8 more
doaj   +1 more source

Prevalence of QTc interval prolongation and its associated risk factors among psychiatric patients: a prospective observational study

BMC Psychiatry, 2020
Background QT interval prolongation is a growing concern worldwide, posing psychiatric patients to life-threatening fatal arrhythmias i.e., torsade de pointes.
Zahid Ali, Mohammad Ismail, Zahid Nazar, Fahadullah Khan, Qasim Khan, Sidra Noor   +5 more
doaj   +1 more source

Trigger versus Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator [PDF]

, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Antzelevitch, Antzelevitch, Benson, Benson, Benson, Benson, Bezekci, Bilet, Bohnen, Camm, Campos, Clancy, Clayton, Clusin, Colman, Colman, Drouin, Dutta, Glukhov, Grunnet, Guo, Hansen, Hart, Janse, Kalin, Kléber, Kumar, Lankipalli, Li, Lou, Mann, Mirams, Moss, Nachimuthu, Noble, Němec, O'Hara, Pandit, Peitersen, Perez Alday, Perez Alday, Perez Alday, Ratner, Restrepo, Rush, Schwartz, Shaw, Smaill, Starmer, Strom, ten Tusscher, Tomaselli, Tse, Venetucci, Vinet, Wagner, Walton, Wu   +57 more
core   +2 more sources

Integrating ZnO/Ag2O@g‐C3N4‐Based Nanocomposites Into a Carrageenan Matrix to Efficiently Remove Heavy Metals From Water

Advanced Materials Interfaces, EarlyView.
ABSTRACT This research focused on characterizing graphitic carbon nitride (g‐C3N4) nanocomposites incorporated with ZnO and Ag2O nanoparticles, and carrageenan to remove heavy metals. The ZnO/Ag2O@ g‐C3N4 and ZnO/Ag2O/g‐C3N4@Carr nanocomposites demonstrated thermal stability of 97.40% (108.81°C) and 82.80% (188.99°C) for TGA.
Feziwe B. Mamba, Bhekani S. Mbuli, James Ramontja   +2 more
wiley   +1 more source

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]

, 2015
A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den, Eijgelsheim, M. (Mark), Niemeijer, M.N. (Maartje), Rijnbeek, P.R. (Peter), Stricker, B.H.Ch. (Bruno)   +4 more
core   +1 more source

Microfluidic Engineering of Chitosan‐Coated Nanoemulsions for Controlled Release and Stability in Space Pharmaceutics

Advanced Materials Technologies, EarlyView.
Microfluidic engineering enables the fabrication of chitosan‐coated, melatonin‐loaded nanoemulsions with controlled release and enhanced physicochemical stability for space pharmaceutics. Interfacial biopolymer coating modulates droplet behavior under accelerated thermal stress and simulated microgravity.
Modupe Adebowale, Nguyen Van Duc Long, Philip M Williams, Volker Hessel   +3 more
wiley   +1 more source

Transient Long QT Development in a Patient with Takotsubo Cardiomyopathy

Journal of Cardiovascular Emergencies, 2016
QT interval prolongation on the electrocardiogram is considered a precursory sign for imminent, potentially lethal ventricular arrhythmias. Beside the inherited condition of long QT syndrome, numerous drugs, certain electrolyte disturbances and early ...
Czuriga Dániel, Szegedi Andrea, Győry Ferenc, Szilágyi Attila, Sipka Sándor, Kertész Attila, Fülöp László, Czuriga István, Péter Andrea, Édes István, Bódi Annamária   +10 more
doaj   +1 more source

Direct Gravity‐Induced Modulation of Cardiac Conduction Pathways Evidenced Through Propagation Features in Electrophysiological Mapping

Advanced Materials Technologies, EarlyView.
A high‐density wearable body‐surface potential mapping array reveals how gravity reshapes cardiac conduction in real time. By resolving spatiotemporal delay patterns invisible to conventional ECG, the platform uncovers posture‐dependent electrophysiological adaptations across the thorax.
Ruben Ruiz‐Mateos Serrano, Matias L. Picchio, Daniele Mantione, David Mecerreyes, George G. Malliaras   +4 more
wiley   +1 more source