Results 51 to 60 of about 180,206 (347)

Thoracic epidural analgesia prolongs postoperative QT interval on electrocardiogram in major non-cardiac surgery: a randomized comparison and a prospective cohort analysis

Frontiers in Pharmacology, 2023
Introduction: Prolongation of QT interval on electrocardiogram can be associated with perioperative lethal arrhythmia. Epidural analgesia is a commonly used modality to relieve surgical pain by blocking sensory nerves, which also blocks the autonomic ...
Kotaro Hori, Shogo Tsujikawa, Mika Egami, Sayaka Waki, Ryota Watanabe, Hideki Hino, Tadashi Matsuura, Takashi Mori   +7 more
doaj   +1 more source

In silico investigation of a KCNQ1 mutation associated with short QT syndrome [PDF]

, 2017
Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death.
A El Harchi, A Mazzanti, C Antzelevitch, C Bellocq, C Giustetto, C Giustetto, C Lerche, C Moreno, C Patel, C Templin, DG Whittaker, DL Weiss, F Gaita, H Watanabe, H Zhang, I Adeniran, I Gussak, J Barhanin, J Silva, JA Nelder, K Gima, K Hong, KHWJ Tusscher, KHWJ Tusscher Ten, KHWJten Tusscher, L Priebe, L Restier, MC Sanguinetti, MJ Curtis, MP Nash, O Anttonen, P Bjerregaard, P Maury, R Schimpf, R Schimpf, R Schimpf, R Schimpf, R Schimpf, R Towart, RH Clayton, RH Keldermann, RS Duncan, S Frea, T O’Hara, Z-J Wu   +44 more
core   +4 more sources

Dual‐Ligand Metal‐Organic Frameworks via In Situ Amidoxime Engineering for Selective Ion Separation

Advanced Functional Materials, EarlyView.
Inspired by microbial ion‐trapping mechanisms, a mild and universal strategy is developed to construct highly porous amidoxime‐functionalized MOFs. DFT calculations and molecular force measurements reveal that the dual‐ligand amidoxime configuration significantly strengthens Ga(III) affinity.
Zhifang Lv, Guixia Fan, Yun Bai, Guosheng Li, Peng Li, Wenjihao Hu, Yijun Cao, Wenshuai Yang, Daoguang Teng, Hongbo Zeng   +9 more
wiley   +1 more source

Trigger versus Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator [PDF]

, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Antzelevitch, Antzelevitch, Benson, Benson, Benson, Benson, Bezekci, Bilet, Bohnen, Camm, Campos, Clancy, Clayton, Clusin, Colman, Colman, Drouin, Dutta, Glukhov, Grunnet, Guo, Hansen, Hart, Janse, Kalin, Kléber, Kumar, Lankipalli, Li, Lou, Mann, Mirams, Moss, Nachimuthu, Noble, Němec, O'Hara, Pandit, Peitersen, Perez Alday, Perez Alday, Perez Alday, Ratner, Restrepo, Rush, Schwartz, Shaw, Smaill, Starmer, Strom, ten Tusscher, Tomaselli, Tse, Venetucci, Vinet, Wagner, Walton, Wu   +57 more
core   +2 more sources

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Journal of Pharmacological Sciences, 2019
Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation.
Petr Vesely, Tibor Stracina, Miroslava Hlavacova, Josef Halamek, Jana Kolarova, Veronika Olejnickova, Veronika Mrkvicova, Hana Paulova, Marie Novakova   +8 more
doaj   +1 more source

Non‐PFAS‐Based Magnetic Polymer Sorbents for Efficient Removal of Perfluorinated Compounds from Landfill Leachate

Advanced Materials, EarlyView.
Magnetic polymer sorbents featuring non‐per‐ and polyfluoroalkyl substances (non‐PFAS)‐based fluorinated and cationic groups enable selective and efficient removal of multiple PFAS from complex landfill leachate. By optimizing functional group balance and polymer design, the sorbents achieve >90% removal, excellent reusability, and outperform ...
Xiao Tan, Zhuojing Yang, Zhou Chen, Yutong Zhu, Chunrong Yu, Yiqing Wang, Kehan Liu, Pradeep Dewapriya, Xuemei Li, Zicheng Su, Marcus J. Giansiracusa, Colette Boskovic, Biao Wang, Kevin V. Thomas, Cheng Zhang   +14 more
wiley   +1 more source

Transient Long QT Development in a Patient with Takotsubo Cardiomyopathy

Journal of Cardiovascular Emergencies, 2016
QT interval prolongation on the electrocardiogram is considered a precursory sign for imminent, potentially lethal ventricular arrhythmias. Beside the inherited condition of long QT syndrome, numerous drugs, certain electrolyte disturbances and early ...
Czuriga Dániel, Szegedi Andrea, Győry Ferenc, Szilágyi Attila, Sipka Sándor, Kertész Attila, Fülöp László, Czuriga István, Péter Andrea, Édes István, Bódi Annamária   +10 more
doaj   +1 more source

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen family study [PDF]

, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies of ...
Amin, N. (Najaf), Axenovich, T.I. (Tatiana), Berg, M.E. (Marten) van den, Demirkan, A. (Ayşe), Duijn, C.M. (Cornelia) van, Isaacs, A.J. (Aaron), Kirichenko, A.V. (Anatoly), Kors, J.A. (Jan), Leeuwen, E.M. (Elisa) van, Oostra, B.A. (Ben), Silva Aldana, C.T. (Claudia), Stricker, B.H.Ch. (Bruno), Uitterlinden, A.G. (André), Willemsen, R. (Rob), Witteman, J.C.M. (Jacqueline), Zorkoltseva, I.V. (Irina)   +15 more
core   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source