Results 51 to 60 of about 182,594 (345)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome [PDF]

, 2017
Short QT syndrome (SQTS) is a rare condition characterized by abnormally ‘short’ QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death.
A El Harchi, A Mazzanti, C Antzelevitch, C Bellocq, C Giustetto, C Giustetto, C Lerche, C Moreno, C Patel, C Templin, DG Whittaker, DL Weiss, F Gaita, H Watanabe, H Zhang, I Adeniran, I Gussak, J Barhanin, J Silva, JA Nelder, K Gima, K Hong, KHWJ Tusscher, KHWJ Tusscher Ten, KHWJten Tusscher, L Priebe, L Restier, MC Sanguinetti, MJ Curtis, MP Nash, O Anttonen, P Bjerregaard, P Maury, R Schimpf, R Schimpf, R Schimpf, R Schimpf, R Schimpf, R Towart, RH Clayton, RH Keldermann, RS Duncan, S Frea, T O’Hara, Z-J Wu   +44 more
core   +4 more sources

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Journal of Pharmacological Sciences, 2019
Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation.
Petr Vesely, Tibor Stracina, Miroslava Hlavacova, Josef Halamek, Jana Kolarova, Veronika Olejnickova, Veronika Mrkvicova, Hana Paulova, Marie Novakova   +8 more
doaj   +1 more source

Acute effects of coffee on QT interval in healthy subjects [PDF]

, 2011
The coronary endothelial function is recognized to have an important role in the physiology of the diastolic ventricular relaxation, a phase of the heart cycle that influences the electrocardiographic QT interval.
BUSCEMI, Silvio, Mattina, A, Tranchina, MR, VERGA, Salvatore   +3 more
core   +3 more sources

Molecular Surface Engineering of Sulfide Electrolytes with Enhanced Humidity Tolerance for Robust Lithium Metal All‐Solid‐State Batteries

Advanced Materials, EarlyView.
It is demonstrated that the electrochemical, interfacial, and humidity stability of halide‐doped sulfide electrolytes (LPSClBr) is significantly enhanced by an organic surface coating using octadecyl phosphonic acid (OPA) and its lithiated form (Li‐OPA). This single‐step strategy enables robust interfacial protection, supports lithium metal anodes, and
Laras Fadillah, Leonie Braks, Jihoon Oh, Mingliang Liu, Hanna Türk, Davide Tisi, Mounir Mensi, Michele Ceriotti, Jang Wook Choi, Ali Coskun   +9 more
wiley   +1 more source

Transient Long QT Development in a Patient with Takotsubo Cardiomyopathy

Journal of Cardiovascular Emergencies, 2016
QT interval prolongation on the electrocardiogram is considered a precursory sign for imminent, potentially lethal ventricular arrhythmias. Beside the inherited condition of long QT syndrome, numerous drugs, certain electrolyte disturbances and early ...
Czuriga Dániel, Szegedi Andrea, Győry Ferenc, Szilágyi Attila, Sipka Sándor, Kertész Attila, Fülöp László, Czuriga István, Péter Andrea, Édes István, Bódi Annamária   +10 more
doaj   +1 more source

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen family study [PDF]

, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies of ...
Amin, N. (Najaf), Axenovich, T.I. (Tatiana), Berg, M.E. (Marten) van den, Demirkan, A. (Ayşe), Duijn, C.M. (Cornelia) van, Isaacs, A.J. (Aaron), Kirichenko, A.V. (Anatoly), Kors, J.A. (Jan), Leeuwen, E.M. (Elisa) van, Oostra, B.A. (Ben), Silva Aldana, C.T. (Claudia), Stricker, B.H.Ch. (Bruno), Uitterlinden, A.G. (André), Willemsen, R. (Rob), Witteman, J.C.M. (Jacqueline), Zorkoltseva, I.V. (Irina)   +15 more
core   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute pancreatitis

Acta Medica Alanya, 2020
Aim: Acute pancreatitis may affect cardiovascular system regardless of etiology. Electrocardiographic parameters such as QT interval, corrected QT interval (QTc), Tp-e interval and Tp-e/QT, Tp-e/QTc ratio can be used to evaluate myocardial repolarization.
Yilmaz Güler, Can Ramazan Öncel
doaj   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source