Results 81 to 90 of about 182,594 (345)

Electrocardiogram alterations following one-week consumption of Crocus sativus L. (saffron) [PDF]

, 2012
Considering the global popularity and also the various biological and medicinal properties of saffron, this study was conducted to assess the influence of its aqueous extracts administration on blood pressure, pressure-rate product (PRP) and ...
Joukar, Siyavash
core  

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Meta-analysis of T peak –T end and T peak –T end /QT ratio for risk stratification in congenital long QT syndrome [PDF]

, 2018
Background and objectives: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death.
Baranchuk, Adrian M., Bazoukis, George, Georgopoulos, Stamatis, Gong, Mengqi, Letsas, Konstantinos P., Liu, Tong, Meng, Lei, Tse, Gary, Vassiliou, Vassilios S., Wong, Cheuk Wai, Wong, Martin C.S., Xia, Yunlong, Yan, Gan-Xin   +12 more
core   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

THE WAYS TO ENHANCE SAFETY OF COMBINATIONS OF DRUGS PROLONGING QT INTERVAL IN THE OUT-PATIENT AND POLYCLINIC PRACTICE

Вестник анестезиологии и реаниматологии, 2018
Prolongation of QT interval is a predictor of fatal disorders of cardiac rhythm and sudden death. Side effects of medications is one of the main causes of prolonged QT interval.
E. V. Shikh, Zh. M. Sizova, A. D. Ismagilov, M. A. Vyzhigina   +3 more
doaj   +1 more source

Solifenacin linked QT interval prolongation and torsades de pointes [PDF]

, 2017
[no ...
Bray, Jonathan, Hancox, Jules
core   +2 more sources

Evaluation of clinical cardiac safety of zilurgisertib, an activin receptor‐like kinase‐2 (ALK2) inhibitor, in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract The oral, small molecule inhibitor of activin receptor‐like kinase‐2, zilurgisertib (INCB000928), is under evaluation in fibrodysplasia ossificans progressiva. Cardiac safety was assessed using electrocardiogram (ECG) parameters and a plasma concentration‐heart rate‐corrected QT (C‐QTc) interval analysis of pooled data from single ascending ...
Yan‐ou Yang, Hong Yang, Xing Liu, Xiaohua Gong, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Incidencia de QT corto y largo en alumnos de primer ingreso a Facultad de Deportes [PDF]

, 2015
Las alteraciones electrocardiográficas del intervalo QT (síndrome de QT corto y largo) están asociadas a un riesgo elevado de muerte súbita por arritmias ventriculares malignas y a episodios de fibrilación auricular.
Arce Guridi, Raquel Citlalli, Chávez López, Carlos Alberto, Galarraga Triana, Edgar Ney, Pineda Espejel, Heriberto Antonio, Trejo Trejo, Marina   +4 more
core  

Electrocardiographic T-wave peak-to-end interval for hypoglycaemia detection. [PDF]

, 2010
Electrocardiographic T wave peak-to-end interval (TpTe) is one parameter of T wave morphology, which contains indicators for hypoglycaemia. This paper shows the corrected TpTe (TpTe(c)) interval as one of the inputs contributing to detect hypoglycaemia ...
Nguyen, HT, Nuryani, SL
core   +1 more source