Results 81 to 90 of about 180,206 (347)

PAMPS PolyHIPEs: The Role of Shape, Porosity, and Sulfonate Group Density on Metal‐Ion Adsorption From Water

Journal of Applied Polymer Science, EarlyView.
This study demonstrates how pore architecture, shape, and sulfonate group density influence the adsorption of Zn2+, Fe3+, and Al3+ by PAMPS polyHIPEs. Beads and monoliths exhibit distinct transport behavior compared to commercial 77H resin. The results offer design guidelines for optimizing ion‐exchange polymers to improve performance in water ...
Sebastijan Kovačič, Roko Vladušić
wiley   +1 more source

Electrocardiogram alterations following one-week consumption of Crocus sativus L. (saffron) [PDF]

, 2012
Considering the global popularity and also the various biological and medicinal properties of saffron, this study was conducted to assess the influence of its aqueous extracts administration on blood pressure, pressure-rate product (PRP) and ...
Joukar, Siyavash
core  

Electrocardiographic T-wave peak-to-end interval for hypoglycaemia detection. [PDF]

, 2010
Electrocardiographic T wave peak-to-end interval (TpTe) is one parameter of T wave morphology, which contains indicators for hypoglycaemia. This paper shows the corrected TpTe (TpTe(c)) interval as one of the inputs contributing to detect hypoglycaemia ...
Nguyen, HT, Nuryani, SL
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Drink, Drugs, and the QT Interval [PDF]

Clinical Cardiology, 2010
AbstractThe effects of several prescription and illicitly‐used drugs on electrocardiographic repolarization are well documented, most frequently manifested as prolongation of the corrected QT (QTc) interval. The combination of multiple repolarization‐modulating drugs taken in high dosage can occasionally lead to extreme abnormalities of the QTc ...
Robin A P, Weir, Colin J, Petrie, Charles Angus, Murphy, Henry J, Dargie   +3 more
openaire   +2 more sources

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Meta-analysis of T peak –T end and T peak –T end /QT ratio for risk stratification in congenital long QT syndrome [PDF]

, 2018
Background and objectives: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death.
Baranchuk, Adrian M., Bazoukis, George, Georgopoulos, Stamatis, Gong, Mengqi, Letsas, Konstantinos P., Liu, Tong, Meng, Lei, Tse, Gary, Vassiliou, Vassilios S., Wong, Cheuk Wai, Wong, Martin C.S., Xia, Yunlong, Yan, Gan-Xin   +12 more
core   +1 more source

QT Interval and QT Variability

, 2012
Sudden cardiac death (SCD) is among the most common types of mortality in developed countries. It for more deaths each year than the total number of deaths from AIDS, breast cancer, lung cancer and stroke together. SCD accounts for approximately 50% of all deaths from cardiovascular diseases and 20% of total mortality (1).
Vrtovec, Bojan, Poglajen, Gregor
openaire   +3 more sources

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source